Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Automatic assignment of GO terms using logical inference
Buffy, a Drosophila Bcl-2 protein, has anti-apoptotic and cell cycle inhibitory functions.
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Buffy is a pro-survival Bcl-2 family protein
"Buffy, the second Drosophila Bcl-2-like protein, is a pro-survival protein"
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Overexpression inhibits developmental and irradiation-induced apoptosis
"overexpression of buffy results in the inhibition of developmental programmed cell death and gamma irradiation-induced apoptosis"
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Physically and genetically interacts with Debcl to suppress cell death
"Buffy interacts genetically and physically with Debcl to suppress Debcl-induced cell death"
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Acts downstream of Rpr, Grim, Hid and upstream of Dronc
"Genetic interactions suggest that Buffy acts downstream of Rpr, Grim and Hid, and upstream of the apical caspase Dronc"
Molecular determinants of the subcellular localization of the Drosophila Bcl-2 homologues DEBCL and BUFFY.
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Buffy localizes to endoplasmic reticulum, not mitochondria
"these two proteins localize to distinct intracellular membranes, DEBCL predominantly to mitochondria and BUFFY to endoplasmic reticula (ER)"
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Debcl localizes to mitochondria
"DEBCL predominantly to mitochondria"
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C-terminal membrane anchor required for localization
"The MA in both proteins is required for the correct targeting"
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Lack of basic residues in Buffy MA allows ER targeting
"The C-terminal positively charged residues present in DEBCL are absent in BUFFY, which allows for its localization to ER"
Effector caspase Dcp-1 and IAP protein Bruce regulate starvation-induced autophagy during Drosophila melanogaster oogenesis.
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Buffy identified as regulator of starvation-induced autophagy
"six cell death genes--death caspase-1 (Dcp-1), hid, Bruce, Buffy, debcl, and p53-as well as Ras-Raf-mitogen activated protein kinase signaling pathway components had a role in autophagy regulation"
grim promotes programmed cell death of Drosophila microchaete glial cells.
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Buffy has context-dependent pro-apoptotic role
"This is the first example of a developmental PCD process influenced by buffy, and places buffy in a proapoptotic role"
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Loss of Buffy causes glial cell survival in microchaete lineage
"Loss of buffy led to microchaete glial cell survival"
Alternative germ cell death pathway in Drosophila involves HtrA2/Omi, lysosomes, and a caspase-9 counterpart.
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Describes alternative germ cell death pathway involving Dronc, HtrA2, lysosomes
"germ cell death (GCD) involves the initiator caspase Dronc independently of the apoptosome and the main executioner caspases"
Evidence for existence of an apoptosis-inducing BH3-only protein, sayonara, in Drosophila.
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Sayonara is first Drosophila BH3-only protein
"Here, we identify the first Drosophila BH3-only protein and name it sayonara"
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Interacts genetically and biochemically with Buffy and Debcl
"Sayonara induces apoptosis in a BH3 motif-dependent manner and interacts genetically and biochemically with the BCL-2 homologous proteins, Buffy and Debcl"
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Forms complexes with both Bcl-2 proteins
"GST-Synr pulls down both Flag-Buffy and HA-Debcl simultaneously, suggesting a possibility of complex formation among Synr, Buffy and Debcl"
Deep research synthesis on Buffy/dBorg-2 Bcl-2 family function