Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic Gene Ontology annotation based on Rhea mapping
Combined Automated Annotation using Multiple IEA Methods
stumps, a Drosophila gene required for fibroblast growth factor (FGF)-directed migrations of tracheal and mesodermal cells.
PTP-ER, a novel tyrosine phosphatase, functions downstream of Ras1 to downregulate MAP kinase during Drosophila eye development.
Genetic analysis of rolled, which encodes a Drosophila mitogen-activated protein kinase.
Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways.
Role of the EGFR/Ras/Raf pathway in specification of photoreceptor cells in the Drosophila retina.
Mae mediates MAP kinase phosphorylation of Ets transcription factors in Drosophila.
Guidance of cell migration by the Drosophila PDGF/VEGF receptor.
MASK, a large ankyrin repeat and KH domain-containing protein involved in Drosophila receptor tyrosine kinase signaling.
KSR is a scaffold required for activation of the ERK/MAPK module.
Developmental control of blood cell migration by the Drosophila VEGF pathway.
Keren, a new ligand of the Drosophila epidermal growth factor receptor, undergoes two modes of cleavage.
Ligand-dependent activation of breathless FGF receptor gene in Drosophila developing trachea.
FGF is an essential mitogen and chemoattractant for the air sacs of the drosophila tracheal system.
Species-specific activation of EGF receptor signaling underlies evolutionary diversity in the dorsal appendage number of the genus Drosophila eggshells.
Primary structure, expression, and signal-dependent tyrosine phosphorylation of a Drosophila homolog of extracellular signal-regulated kinase.
Downstream-of-FGFR is a fibroblast growth factor-specific scaffolding protein and recruits Corkscrew upon receptor activation.
FGF8-like1 and FGF8-like2 encode putative ligands of the FGF receptor Htl and are required for mesoderm migration in the Drosophila gastrula.
Drosophila PI3 kinase and Akt involved in insulin-stimulated proliferation and ERK pathway activation in Schneider cells.
PVR plays a critical role via JNK activation in thorax closure during Drosophila metamorphosis.
The Drosophila protein kinase LK6 is regulated by ERK and phosphorylates the eukaryotic initiation factor eIF4E in vivo.
Conserved cross-interactions in Drosophila and Xenopus between Ras/MAPK signaling and the dual-specificity phosphatase MKP3.
Dynamic EGFR-Ras signalling in Drosophila leg development.
MAP kinase subcellular localization controls both pattern and proliferation in the developing Drosophila wing.
Mae inhibits Pointed-P2 transcriptional activity by blocking its MAPK docking site.
D-MEKK1, the Drosophila orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediate the activation of D-JNK by cadmium and arsenite in Schneider cells.
A KSR/CNK complex mediated by HYP, a novel SAM domain-containing protein, regulates RAS-dependent RAF activation in Drosophila.
Inhibition of ERK-MAP kinase signaling by RSK during Drosophila development.
A MAPK docking site is critical for downregulation of Capicua by Torso and EGFR RTK signaling.
Chimaerin and Rac regulate cell number, adherens junctions, and ERK MAP kinase signaling in the Drosophila eye.
Boss/Sev signaling from germline to soma restricts germline-stem-cell-niche formation in the anterior region of Drosophila male gonads.
Gliatrophic and gliatropic roles of PVF/PVR signaling during axon guidance.
Multiple RTK pathways downregulate Groucho-mediated repression in Drosophila embryogenesis.
Nuclear trapping shapes the terminal gradient in the Drosophila embryo.
Effector caspase Dcp-1 and IAP protein Bruce regulate starvation-induced autophagy during Drosophila melanogaster oogenesis.
EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors.
Unc-51 controls active zone density and protein composition by downregulating ERK signaling.
PDGF/VEGF signaling controls cell size in Drosophila.
Happyhour, a Ste20 family kinase, implicates EGFR signaling in ethanol-induced behaviors.
The insect neuropeptide PTTH activates receptor tyrosine kinase torso to initiate metamorphosis.
A novel conserved phosphotyrosine motif in the Drosophila fibroblast growth factor signaling adaptor Dof with a redundant role in signal transmission.
β-arrestin Kurtz inhibits MAPK and Toll signalling in Drosophila development.
Hole-in-one mutant phenotypes link EGFR/ERK signaling to epithelial tissue repair in Drosophila.
Chemical genetic discovery of targets and anti-targets for cancer polypharmacology.
The Drosophila Arf GEF Steppke controls MAPK activation in EGFR signaling.
Extracellular matrix-modulated Heartless signaling in Drosophila blood progenitors regulates their differentiation via a Ras/ETS/FOG pathway and target of rapamycin function.
The nuclear lamina regulates germline stem cell niche organization via modulation of EGFR signaling.
Platelet-derived growth factor/vascular endothelial growth factor receptor inactivation by sunitinib results in Tsc1/Tsc2-dependent inhibition of TORC1.
ERK signaling couples nutrient status to antiviral defense in the insect gut.
Fragile X mental retardation protein regulates trans-synaptic signaling in Drosophila.
Tay bridge is a negative regulator of EGFR signalling and interacts with Erk and Mkp3 in the Drosophila melanogaster wing.
A functional screen reveals an extensive layer of transcriptional and splicing control underlying RAS/MAPK signaling in Drosophila.
Slik and the receptor tyrosine kinase Breathless mediate localized activation of Moesin in terminal tracheal cells.
Switching between humoral and cellular immune responses in Drosophila is guided by the cytokine GBP.
Cardiac hypertrophy induced by active Raf depends on Yorkie-mediated transcription.
A systems-level interrogation identifies regulators of Drosophila blood cell number and survival.
The Ras-Erk-ETS-Signaling Pathway Is a Drug Target for Longevity.
Minibrain and Wings apart control organ growth and tissue patterning through down-regulation of Capicua.
Divergent effects of intrinsically active MEK variants on developmental Ras signaling.
A Switch-like Activation Relay of EGFR-ERK Signaling Regulates a Wave of Cellular Contractility for Epithelial Invagination.
Feedback regulation of cytoneme-mediated transport shapes a tissue-specific FGF morphogen gradient.
Tumor-Derived Ligands Trigger Tumor Growth and Host Wasting via Differential MEK Activation.
Secreted Spitz triggers the DER signaling pathway and is a limiting component in embryonic ventral ectoderm determination.
The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway.
The ETS domain protein pointed-P2 is a target of MAP kinase in the sevenless signal transduction pathway.
A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways.
The Drosophila rolled locus encodes a MAP kinase required in the sevenless signal transduction pathway.
The sevenless signalling cassette mediates Drosophila EGF receptor function during epidermal development.
A screen for genes that function downstream of Ras1 during Drosophila eye development.
Biochemical characterization of rolledSem, an activated form of Drosophila mitogen-activated protein kinase.
The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye.
EGF domain swap converts a drosophila EGF receptor activator into an inhibitor.
Dissecting the roles of the Drosophila EGF receptor in eye development and MAP kinase activation.
Regulation of EGF receptor signaling establishes pattern across the developing Drosophila retina.
Quantitative variations in the level of MAPK activity control patterning of the embryonic termini in Drosophila.