Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Inhibition of tyrosine kinase activation blocks the down-regulation of CXC chemokine receptor 4 by HIV-1 gp120 in CD4+ T cells.
Conformational changes of gp120 in epitopes near the CCR5 binding site are induced by CD4 and a CD4 miniprotein mimetic.
Interactions of CCR5 and CXCR4 with CD4 and gp120 in human blood monocyte-derived dendritic cells.
Energetics of the HIV gp120-CD4 binding reaction.
Cloning of ACP33 as a novel intracellular ligand of CD4.
Direct in vitro binding of full-length human immunodeficiency virus type 1 Nef protein to CD4 cytoplasmic domain.
The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain.
Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule.
Disulfide exchange in domain 2 of CD4 is required for entry of HIV-1.
CD4 dimers constitute the functional component required for T cell activation.
Lipid raft distribution of CD4 depends on its palmitoylation and association with Lck, and evidence for CD4-induced lipid raft aggregation as an additional mechanism to enhance CD3 signaling.
CD4 raft association and signaling regulate molecular clustering at the immunological synapse site.
Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail.
Constitutive association of cell surface CCR5 and CXCR4 in the presence of CD4.
Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN.
Growth transformation of human T cells by herpesvirus saimiri requires multiple Tip-Lck interaction motifs.
FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection.
Structural definition of a conserved neutralization epitope on HIV-1 gp120.
Adhesion versus coreceptor function of CD4 and CD8: role of the cytoplasmic tail in coreceptor activity.
The phospholipid scramblases 1 and 4 are cellular receptors for the secretory leukocyte protease inhibitor and interact with CD4 at the plasma membrane.
NMR structure of the transmembrane and cytoplasmic domains of human CD4 in micelles.
Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility.
Structure of a clade C HIV-1 gp120 bound to CD4 and CD4-induced antibody reveals anti-CD4 polyreactivity.
Deubiquitinases sharpen substrate discrimination during membrane protein degradation from the ER.
CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection.
Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env.
Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions.
Structure of a Potential Therapeutic Antibody Bound to Interleukin-16 (IL-16): MECHANISTIC INSIGHTS AND NEW THERAPEUTIC OPPORTUNITIES.
Interaction between CD4 and class II MHC molecules mediates cell adhesion.
The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family.
Structural basis of coreceptor recognition by HIV-1 envelope spike.
The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Interaction of p56lck with CD4 in the yeast two-hybrid system.
Human immunodeficiency virus type 1 Nef and p56lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tail.
Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain.
Role of CD4 and CD8 in T cell activation and differentiation.
A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors.
Dimeric association and segmental variability in the structure of human CD4.
Processing and activation of pro-interleukin-16 by caspase-3.
The level of CD4 surface protein influences T cell selection in the thymus.
Dendritic cells express multiple chemokine receptors used as coreceptors for HIV entry.
Solution structure of the cytoplasmic domain of the human CD4 glycoprotein by CD and 1H NMR spectroscopy: implications for biological functions.
Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody.
A Zn2+ ion links the cytoplasmic tail of CD4 and the N-terminal region of Lck.
HIV-1 envelope gp120 inhibits the monocyte response to chemokines through CD4 signal-dependent chemokine receptor down-regulation.
Conformational changes in gp120 exposes gp41
CD4:gp120 binds to chemokine co-receptor CCR5/CXCR4
N and C terminal heptad repeat helices of gp41 form six-helix bundle
Binding of gp120 of ENV oligomer to the host CD4
Conformational change in gp120 of Env oligomer
Fusogenic activation of gp41
Insertion of gp41 fusion peptide into the target membrane
Fusion of viral membrane with host cell membrane
Formation of CD4:Nef:AP-2 Complex:v-ATPase Complex
Nef mediated disruption of CD4:Lck Complex
Internalization of the CD4:Nef:AP-2 Complex:v-ATPase Complex
Degradation of ubiquitinated CD4
Vpu:CD4 associates with beta-TrCP
Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex
The Vpu:CD4:beta-TrCP complex recruits SKP1
Association of Vpu with CD4
Formation of a Nef:ARF1:CD4 complex
Phosphorylation of ITAM motifs in CD3 complexes
Phosphorylation of ZAP-70 by Lck
Dephosphorylation of Lck-pY505 by CD45
Phosphorylation of SLP-76
Inactivation of Lck by Csk
Phosphorylation of TBSMs in LAT
Phosphorylation of PLC-gamma1
Change of PKC theta conformation
Recruitment of ZAP-70 to phosphorylated ITAMs
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases
Inactivation of LCK by PTPN22
PTPN22 dephosphorylates ZAP70
AP-2 directly binds some endocytic cargo
F- and N- BAR domain proteins bind the clathrin-coated pit
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit
Clathrin recruits PIK3C2A
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2
SNX9 recruits components of the actin polymerizing machinery
BAR domain proteins recruit dynamin
SYNJ hydrolyze PI(4,5)P2 to PI(4)P
Endophilins recruit synaptojanins to the clathrin-coated pit
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating
Clathrin recruits auxilins to the clathrin-coated vesicle
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle
Dynamin-mediated GTP hydrolysis promotes vesicle scission
Dissociation of clathrin-associated proteins
Dissociation of AAK1 and dephosphorylation of AP-2 mu2
RAB5 and GAPVD1 bind AP-2
A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8.
Affinity maturation of human CD4 by yeast surface display and crystal structure of a CD4-HLA-DR1 complex.
Oligomerization of CD4 is required for stable binding to class II major histocompatibility complex proteins but not for interaction with human immunodeficiency virus gp120.
Lymphocyte chemoattractant factor induces CD4-dependent intracytoplasmic signaling in lymphocytes.
Complete Multilineage CD4 Expression Defect Associated With Warts Due to an Inherited Homozygous CD4 Gene Mutation.
Helper T cell immunity in humans with inherited CD4 deficiency.
The CD4 and CD3δε Cytosolic Juxtamembrane Regions Are Proximal within a Compact TCR-CD3-pMHC-CD4 Macrocomplex.
Dual Role of CD4 in Peripheral T Lymphocytes.
Proteomic-based identification of CD4-interacting proteins in human primary macrophages.
CD4 deep research report (falcon / Edison Scientific)