Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
Annotation inferences using phylogenetic trees
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2.
A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.
TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis.
FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCepsilon, B-Raf and S6K2.
Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN.
MEKK1 mediates the ubiquitination and degradation of c-Jun in response to osmotic stress.
Negative regulation of MEKK1/2 signaling by serine-threonine kinase 38 (STK38).
ISG15 modification of filamin B negatively regulates the type I interferon-induced JNK signalling pathway.
Expression of the Bcl-2 protein BAD promotes prostate cancer growth.
The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions.
MarvelD3 couples tight junctions to the MEKK1-JNK pathway to regulate cell behavior and survival.
Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1.
Differential activation of stress-activated protein kinase kinases SKK4/MKK7 and SKK1/MKK4 by the mixed-lineage kinase-2 and mitogen-activated protein kinase kinase (MKK) kinase-1.
JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension.
Fc epsilon receptor (FCERI) signaling
Phosphorylation of MEK7 by MEKK1
Phosphorylation of MEK4 by MEKK1
Activation of IKK by MEKK1
The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2.
Ubiquitylation of MEKK1 inhibits its phosphorylation of MKK1 and MKK4 and activation of the ERK1/2 and JNK pathways.
The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines.
A cryptic tubulin-binding domain links MEKK1 to curved tubulin protomers.
Mutations in MAP3K1 cause 46,XY disorders of sex development and implicate a common signal transduction pathway in human testis determination.
Deep research report on MAP3K1 (Falcon)
UniProt entry Q13233 (MAP3K1)