THI12 (YNL332W, P42883) review notes

Identity

• HMP-P synthase THI12; NMT1/THI5 family; function, cofactor and subunit annotated in UniProt by similarity to THI5 (P43534) [UniProt:P42883].
• Member of the four-gene subtelomeric THI5 family PMID:12777485.
• Differs from THI5 at 1 of 340 positions (ungapped comparison of the UniProt sequences in this batch).

Function

• Genetic redundancy for HMP formation PMID:12777485.
• Activity inferred from THI5 biochemistry PMID:23048037 and the Candida orthologue PMID:22568620.
• No direct biochemical or localisation data for THI12 itself.

Curation conclusions

• Core MF GO:0106344 (ISS from THI5, sound given near identity); BP GO:0009228.
• YeastCyc PWY3O-17 omits THI12 (only THI13 is listed for the HMP-P step); the module adds it.