The proapoptotic function of Drosophila Hid is conserved in mammalian cells.
The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID.
Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function.
A steroid-triggered transcriptional hierarchy controls salivary gland cell death during Drosophila metamorphosis.
Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1.
The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis.
Sex-specific apoptosis regulates sexual dimorphism in the Drosophila embryonic gonad.
Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination.
Drosophila melanogaster MNK/Chk2 and p53 regulate multiple DNA repair and apoptotic pathways following DNA damage.
Novel features of cryptochrome-mediated photoreception in the brain circadian clock of Drosophila.
Drosophila myc regulates organ size by inducing cell competition.
Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim.
A balance between the diap1 death inhibitor and reaper and hid death inducers controls steroid-triggered cell death in Drosophila.
Role of programmed cell death in patterning the Drosophila antennal arista.
Genetic dissection of trophic interactions in the larval optic neuropil of Drosophila melanogaster.
Tracheal branch repopulation precedes induction of the Drosophila dorsal air sac primordium.
Mis-specified cells die by an active gene-directed process, and inhibition of this death results in cell fate transformation in Drosophila.
Systematic in vivo RNAi analysis of putative components of the Drosophila cell death machinery.
Local caspase activity directs engulfment of dendrites during pruning.
Embryonic head involution and rotation of male terminalia require the Drosophila locus head involution defective.
DIAP2 functions as a mechanism-based regulator of drICE that contributes to the caspase activity threshold in living cells.
E2F and p53 induce apoptosis independently during Drosophila development but intersect in the context of DNA damage.
Effector caspase Dcp-1 and IAP protein Bruce regulate starvation-induced autophagy during Drosophila melanogaster oogenesis.
Regulation of apoptosis of rbf mutant cells during Drosophila development.
Drosophila microRNAs 263a/b confer robustness during development by protecting nascent sense organs from apoptosis.
Drosophila IAP antagonists form multimeric complexes to promote cell death.
Differential localization and processing of apoptotic proteins in Malpighian tubules of Drosophila during metamorphosis.
Drosophila activated Cdc42 kinase has an anti-apoptotic function.
Drosophila UTX coordinates with p53 to regulate ku80 expression in response to DNA damage.
EGFR signaling coordinates patterning with cell survival during Drosophila epidermal development.
The conserved outer mitochondrial membrane protein Mtch regulates mitophagy during Drosophila intestinal development.
The head involution defective gene of Drosophila melanogaster functions in programmed cell death.
Cooperative functions of the reaper and head involution defective genes in the programmed cell death of Drosophila central nervous system midline cells.
Ras promotes cell survival in Drosophila by downregulating hid expression.
The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling.
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Ras pathway activation inhibits the proapoptotic activity of Hid, and MAPK phosphorylation sites in Hid are required for this inhibition.
"we show that MAPK phosphorylation sites in Hid are critical for this response."
Dredd, a novel effector of the apoptosis activators reaper, grim, and hid in Drosophila.
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Reaper, Grim and Hid expression drives dredd RNA accumulation and processing of the Dredd caspase precursor.
"expression of REAPER, GRIM, and HID was found to trigger processing of DREDD protein precursor through a mechanism that is insensitive to, and upstream of, known caspase inhibitors."
The Drosophila caspase Dredd is required to resist gram-negative bacterial infection.
UniProt entry Q24106 (hid)
FlyBase gene description for hid (DROME)