TMM (At1g80080, Q9SSD1) curation notes

Session 2026-10-06 (stomatal_lineage_development module). Falcon deep research failed (HTTP 402); notes from cached literature.

Identity

• UniProt Q9SSD1 TMM_ARATH (RLP17), 496 aa LRR receptor-like protein, single TM, no kinase domain PMID:22241782.

Key findings

• tmm randomizes orientation of spacing divisions and allows divisions next to stomata -> clusters PMID:11090210; organ-specific: excess stomata in leaves, none in stems [PMID:11536724; PMID:9684356].
• TMM associates with ERECTA and ERL1 in vivo, not with itself PMID:22241782.
• TMM-ERf constitutive complexes are the EPF1/EPF2 receptors; TMM creates the ligand pocket and excludes EPFL4/6 PMID:28536146.
• EPF2 and stomagen bind ER and TMM PMID:26083750; SERKs associate with TMM ligand-independently PMID:26320950.
• Secondary: ABA sensitivity phenotypes [PMID:18434605; PMID:24553751], antifungal immunity with ERf PMID:27446127, trichome overexpression phenotype PMID:24553751.

Curation decisions

• Core MF: coreceptor activity GO:0015026 (added NEW, IDA PMID:28536146); IBA signaling receptor activity accepted as the correct parent.
• Core BP: stomatal complex patterning GO:0010375 (IMP, accepted).
• Generic protein binding: 14-3-3 TAP row REMOVED; stomagen row MODIFIED to peptide binding.
• No GO-CAM models contain TMM.