ATG16L2 notes

2026-10-05 review (PAINT, affinage)

• Complex but no canonical role PMID:22082872.
• Location PMID:22082872.
• NOT rows (ISS from mouse): I accepted NOT autophagosome assembly and NOT autophagosome. NOT autophagy is UNDECIDED, because later mouse knockouts report that ATG16L2 positively regulates LPS-induced autophagy flux [PMID:35426127, abstract-only] and has lineage-specific autophagy roles PMID:31451676.
• Nucleoplasm (HPA IDA) is UNDECIDED: the mouse study judged nuclear EGFP signal a tagging artifact.
• IPI complex row (PMID:23202584): the cached structural paper does not mention ATG16L2. Accepted anyway, deferring to the curator, since the complex is independently established.
• Inflammasome roles (NLRP3, NLRC4/NAIP) come from single abstract-only mouse studies. No NEW terms are proposed; they are recorded in the knowledge gap.

2026-10-05 revision (reviewer round 1)

• NOT autophagy is now ACCEPTed. The later mouse data (PMID:35426127) describe action on the ATG5-12-16L1 complex, which is regulation of autophagy and so compatible with a NOT involved_in row. This matches the NOT autophagosome assembly reasoning.
• core_functions now carries contributes_to_molecular_function GO:0019776 Atg8-family ligase activity, as in the ATG16L1 review PMID:22082872. Caveat: shown only with a membrane-targeted N-terminal fragment (Kras-CAAX fusion).
• PMID:23202584 now has a reference_review, with correctness left unset because support cannot be judged from the cache. The Crohn/SLE description claim now traces to PMID:31451676. The HPA reliability score was not checked.