Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Synaptoporin, a novel putative channel protein of synaptic vesicles.
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Rat synaptoporin copurifies with small synaptic vesicles.
"copurifies with small synaptic vesicles"
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The original channel designation was a homology-based proposal rather than a direct demonstration of ion conductance.
"By homology screening of a rat brain library"
Relative properties and localizations of synaptic vesicle protein isoforms: the case of the synaptophysins.
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Immunoelectron microscopy localized synaptoporin to synaptic vesicles.
"Immunoelectron microscopy confirmed that syp II is localized to synaptic vesicles"
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Synaptoporin is an N-glycosylated membrane protein in a heteromultimeric complex in synaptic-vesicle membranes.
"part of a heteromultimeric complex in synaptic vesicle membranes"
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Heterologously expressed synaptoporin enters the receptor-mediated endocytic pathway.
"targeted to the receptor-mediated endocytosis pathway"
Cloning and sequence analysis of the human cDNA encoding the synaptoporin (delta), a highly conservative synaptic vesicle protein.
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Human SYNPR has two reported splice variants.
"It has two splicing variants"
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Human SYNPR expression was brain-specific in the tested 16-tissue RT-PCR panel.
"specifically expressed in the brain"
Mossy fiber-CA3 synapses mediate homeostatic plasticity in mature hippocampal neurons.
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Presynaptic synaptoporin is required for thorny-excrescence formation.
"TE formation required presynaptic synaptoporin"
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Synaptoporin is required for functional mossy-fiber upregulation and supplies an instructive signal for postsynaptic thorny-excrescence formation or growth.
"Presynaptic synaptoporin was required for functional MF upregulation, and also provides instructive signals necessary for postsynaptic TE formation and/or growth"
Overlapping role of synaptophysin and synaptogyrin family proteins in determining the small size of synaptic vesicles.
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Synaptoporin coexpression with synapsin is sufficient to produce clusters of small vesicles in a heterologous cell assay.
"expression in COS7 cells of each of these three other proteins together with synapsin resulted in the formation of clusters of small vesicles similar in size to those generated by synaptophysin and synapsin coexpression"
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Synaptophysin/synaptogyrin family proteins have overlapping roles in synaptic-vesicle biogenesis and clustering.
"These results point to an overlapping role of these proteins in the biogenesis and clustering of SV"
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The mechanism by which the family determines vesicle shape remains unknown.
"A critical open question to be addressed is how these tetraspanins may determine vesicle shape and whether they do so by an intrinsic property or by recruiting to vesicles other factors with broad expression in neurons and nonneuronal cells"
A proteome-scale map of the human interactome network.
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
UniProt entry for human SYNPR (Q8TBG9)
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UniProt describes SYNPR as an intrinsic membrane protein of small synaptic vesicles.
"Intrinsic membrane protein of small synaptic vesicles"
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The channel assignment is explicitly probable and by similarity.
"Probable vesicular channel protein (By similarity)"
Manual literature synthesis for SYNPR