Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Combined Automated Annotation using Multiple IEA Methods
Deep research report (Falcon) for zebrafish mitfa
nacre encodes a zebrafish microphthalmia-related protein that regulates neural-crest-derived pigment cell fate.
Duplicate mitf genes in zebrafish: complementary expression and conservation of melanogenic potential.
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mitfb is coexpressed with mitfa in the RPE but not in neural crest melanoblasts.
"mitfb is coexpressed with mitfa in the RPE at an appropriate time to compensate for loss of mitfa function in the nacre mutant but is not expressed in neural crest melanoblasts"
Subfunctionalization of duplicate mitf genes associated with differential degeneration of alternative exons in fish.
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Each fish Mitf protein corresponds to one tetrapod MITF isoform.
"Fish proteins MITF-m and MITF-b correspond at both the structural and the expression levels to one particular bird/mammalian MITF isoform."
A requirement for kit in embryonic zebrafish melanocyte differentiation is revealed by melanoblast delay.
Differentiation of zebrafish melanophores depends on transcription factors AP2 alpha and AP2 epsilon.
mitfa is required at multiple stages of melanocyte differentiation but not to establish the melanocyte stem cell.
Otx but not Mitf transcription factors are required for zebrafish retinal pigment epithelium development.
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mitfa, mitfb and double mitf mutants have normal RPE; misexpressed mitfa induces retinal pigmentation.
"the loss of Mitf activity in mitfa, mitfb, or double mitf mutant zebrafish had no effect on RPE pigmentation or development"
On the embryonic origin of adult melanophores: the role of ErbB and Kit signalling in establishing melanophore stem cells in zebrafish.
Local reorganization of xanthophores fine-tunes and colors the striped pattern of zebrafish.
Gap junctions composed of connexins 41.8 and 39.4 are essential for colour pattern formation in zebrafish.
Identification and expression of lypc, a novel dark-inducible member of Ly6 superfamily in zebrafish Danio rerio.
TFAP2 paralogs regulate melanocyte differentiation in parallel with MITF.
Mitf-family transcription factor function is required within cranial neural crest cells to promote choroid fissure closure.
The MITF paralog tfec is required in neural crest development for fate specification of the iridophore lineage from a multipotent pigment cell progenitor.
Fate mapping melanoma persister cells through regression and into recurrent disease in adult zebrafish.
A gene regulatory network combining Pax3/7, Sox10 and Mitf generates diverse pigment cell types in medaka and zebrafish.
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Zebrafish mitfa;mitfb double mutants have fewer trunk xanthophores than mitfa single mutants.
"Compared with a single mitfa mutant, mitfa−/−; mitfb−/− double mutants showed a slightly more severe reduction of xanthophores, with fewer fluorescent xanthophores on the trunk"
Dominant Negative Mitf Allele Impacts Melanophore and Xanthophore Development and Reveals Collaborative Interactions With Tfec in Zebrafish Chromatophore Lineages.
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A dominant-negative mitfa DNA-binding-domain allele removes melanophores and xanthophores.
"Here we identify a new allele of the zebrafish Mitf gene, mitfa, that results in a complete absence of not only melanophores but also yellow-orange xanthophores."
MIT/TFE family transcription factors, Mitf and Tfec, redundantly promote pigment cell differentiation and retinal epithelium pigmentation in teleosts.
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mitfa, mitfb and tfec are jointly required for RPE pigmentation (triple null).
"simultaneous null mutations in all three genes cause a complete loss of all four chromatophore types and lead to defective pigmentation of the retinal pigmented epithelium (RPE)"