How the early sporulation sigma factor sigmaF delays the switch to late development in Bacillus subtilis
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sigG is the late forespore-specific sigma factor
"We report that activity of sigma(G), the late forespore sigma factor, is kept in check by Gin, the product of csfB"
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Interacts with anti-sigma-G factor Gin
"Gin interacts strongly with sigma(G) but not with sigma(F) in a yeast two-hybrid experiment"
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Active only in the forespore
"Sporulation in Bacillus subtilis is a primitive differentiation process involving two cell types, the forespore and the mother cell"
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Gin is the anti-sigma-G factor that prevents premature activation
"Gin allows sigma(F) to delay the switch to the late forespore transcription programme by preventing sigma(G) to take over before the cell has reached a critical stage of development"
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Premature sigma-G activity leads to slow-germinating spores
"Premature sigma(G) activity leads to the formation of slow-germinating spores"
Expression of the sigmaF-directed csfB locus prevents premature appearance of sigmaG activity during sporulation of Bacillus subtilis
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Activity repressed by anti-sigma-G factor Gin (csfB) and Lon protease during early forespore development
"CsfB exerted control distinct from but overlapping with that exerted by LonA to prevent inappropriate sigma(G) activation"
Genetic dissection of an inhibitor of the sporulation sigma factor sigma(G)
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Gin inhibits sigma-G activity by direct physical interaction
"The Gin protein, encoded by csfB, is able to strongly inhibit the activity of one of these factors, sigma(G), in vivo"
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Gin binding to sigma-G may involve more than simple sequestration
"some mutants have kept most of their ability to bind sigma(G) but are completely unable to inhibit sigma(G) transcriptional activity, raising the possibility that Gin might act by a mechanism more complex than just sequestration of sigma(G)"
Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Automatic assignment of GO terms using logical inference, based on inter-ontology links
Combined Automated Annotation using Multiple IEA Methods
Deep research on sigG function