Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Protein misfolding induces hypoxic preconditioning via a subset of the unfolded protein response machinery.
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GCN-2 is required for hypoxic preconditioning (HP) in C. elegans
"GCN-2, which is known to suppress translation and induce an adaptive transcriptional response under conditions of UPR activation or amino acid deprivation, was required for HP"
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HP requires IRE-1 and GCN-2 but not XBP-1 or ATF-6
"HP also required IRE-1 but not XBP-1 or ATF-6"
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eIF2alpha phosphorylation by GCN-2 is not necessary for HP, suggesting other mechanisms
"The phosphorylation of the translation factor eIF2α, an established mechanism of GCN-2-mediated translational suppression, was not necessary for HP"
Protective coupling of mitochondrial function and protein synthesis via the eIF2α kinase GCN-2.
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GCN-2 phosphorylates eIF2alpha in response to mitochondrial dysfunction
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ROS from dysfunctional mitochondria activate GCN-2
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GCN-2 acts in complementary pathway to ATFS-1 for mitochondrial protection
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gcn-2 deletion slows development during mitochondrial stress
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GCN-2 required for lifespan extension in clk-1(qm30) mitochondrial mutants
GCN-2 dependent inhibition of protein synthesis activates osmosensitive gene transcription via WNK and Ste20 kinase signaling.
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Hypertonic stress induces GCN-2-dependent eIF2alpha phosphorylation
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GCN-2 signaling activates gpdh-1 transcription via WNK-1 and GCK-3 kinases
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Loss of gcn-1 or gcn-2 prevents translation inhibition during osmotic stress
The general control nonderepressible-2 kinase mediates stress response and longevity induced by target of rapamycin inactivation in Caenorhabditis elegans.
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GCN-2 phosphorylates eIF2alpha in response to amino acid limitation (krs-1, lrs-1 RNAi)
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atf-5 translation is induced in gcn-2-dependent manner under amino acid starvation
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gcn-2 deletion suppresses lifespan extension in eat-2 dietary restriction mutants
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GCN-2 required for lifespan extension by TOR (let-363) inhibition
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GCN-2 positively regulates pha-4 expression under nutrient stress
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gcn-2 mutants sensitive to heat shock, UV, and oxidative stress
Diverse functions of mRNA metabolism factors in stress defense and aging of Caenorhabditis elegans.
Deep research report on gcn-2