Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Delta-mediated specification of midline cell fates in zebrafish embryos.
The deltaA gene of zebrafish mediates lateral inhibition of hair cells in the inner ear and is regulated by pax2.1.
Delta signaling mediates segregation of neural crest and spinal sensory neurons from zebrafish lateral neural plate.
Three modules of zebrafish Mind bomb work cooperatively to promote Delta ubiquitination and endocytosis.
-
Mib associates with Delta and promotes its ubiquitination and internalization.
"Mind bomb protein displays E3 ubiquitin ligase activity in vitro and that it is associated with Delta and enhances its ubiquitination and internalization in transfected cells"
Rhombomere boundaries are Wnt signaling centers that regulate metameric patterning in the zebrafish hindbrain.
DeltaA mRNA and protein distribution in the zebrafish nervous system.
-
Dla localises in puncta at the membrane and/or cortex, not broadly in cytoplasm.
"Both experiments suggest that in the embryonic spinal cord, Dla protein is localized to puncta at the cell membrane and/or cortex; widespread Dla localization in the cytoplasm is not supported by our data"
DeltaA/DeltaD regulate multiple and temporally distinct phases of notch signaling during dopaminergic neurogenesis in zebrafish.
Basal body proteins regulate Notch signaling through endosomal trafficking.
Different combinations of Notch ligands and receptors regulate V2 interneuron progenitor proliferation and V2a/V2b cell fate determination.
Falcon (Edison Scientific Literature) deep research report for Danio rerio dla (Q6DI48)
-
Mib1 promotes DeltaA internalization.
"Mib1 is a RING-family E3 ubiquitin ligase that promotes DeltaA ubiquitination-dependent internalization; loss of Mib1 causes excessive DeltaA accumulation at the cell surface."