Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Multiple chemosensory defects in daf-11 and daf-21 mutants of Caenorhabditis elegans.
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DAF-21/HSP-90 is required for chemotaxis to volatile and non-volatile attractants
"Multiple chemosensory defects in daf-11 and daf-21 mutants of Caenorhabditis elegans."
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daf-21 mutants have specific sensory defects in AWC neuron-mediated olfaction
"Multiple chemosensory defects in daf-11 and daf-21 mutants of Caenorhabditis elegans."
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HSP-90 likely stabilizes components of cGMP signaling pathway
"Multiple chemosensory defects in daf-11 and daf-21 mutants of Caenorhabditis elegans."
A transmembrane guanylyl cyclase (DAF-11) and Hsp90 (DAF-21) regulate a common set of chemosensory behaviors in Caenorhabditis elegans.
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daf-21 encodes C. elegans HSP90
"A transmembrane guanylyl cyclase (DAF-11) and Hsp90 (DAF-21) regulate a common set of chemosensory behaviors in caenorhabditis elegans."
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The E292K mutation causes chemosensory defects
"A transmembrane guanylyl cyclase (DAF-11) and Hsp90 (DAF-21) regulate a common set of chemosensory behaviors in caenorhabditis elegans."
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daf-21 null is early larval lethal
"A transmembrane guanylyl cyclase (DAF-11) and Hsp90 (DAF-21) regulate a common set of chemosensory behaviors in caenorhabditis elegans."
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DAF-21 likely stabilizes DAF-11 guanylyl cyclase
"A transmembrane guanylyl cyclase (DAF-11) and Hsp90 (DAF-21) regulate a common set of chemosensory behaviors in caenorhabditis elegans."
DAF-7/TGF-beta expression required for the normal larval development in C. elegans is controlled by a presumed guanylyl cyclase DAF-11.
Role of the myosin assembly protein UNC-45 as a molecular chaperone for myosin.
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UNC-45 TPR domain binds HSP90/DAF-21
"Role of the myosin assembly protein UNC-45 as a molecular chaperone for myosin."
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UNC-45 functions as HSP90 co-chaperone for myosin
"Role of the myosin assembly protein UNC-45 as a molecular chaperone for myosin."
Caenorhabditis elegans DAF-21 (HSP90) is characteristically and predominantly expressed in germline cells: spatial and temporal analysis.
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DAF-21 is predominantly expressed in germline cells under normal conditions
"Caenorhabditis elegans DAF-21 (HSP90) is characteristically and predominantly expressed in germline cells: spatial and temporal analysis."
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Under heat stress, expression extends to somatic tissues
"Caenorhabditis elegans DAF-21 (HSP90) is characteristically and predominantly expressed in germline cells: spatial and temporal analysis."
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DAF-21 localizes to perinuclear region of somatic cells
"Caenorhabditis elegans DAF-21 (HSP90) is characteristically and predominantly expressed in germline cells: spatial and temporal analysis."
Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones.
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HSF-1 and chaperones including HSP-90 regulate longevity
"Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones."
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Chaperone networks interact with insulin-like signaling
"Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones."
Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network.
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HSP-90 interacts with DAF-1 TGF-beta receptor
"Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network."
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HSP-90 homodimerizes
"Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network."
Direct and heterologous approaches to identify the LET-756/FGF interactome.
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DAF-21 identified as LET-756/FGF interactor
"Direct and heterologous approaches to identify the LET-756/FGF interactome."
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HSP-90 is involved in chemosensory transduction and insulin signalization
"Direct and heterologous approaches to identify the LET-756/FGF interactome."
Heat-shock transcription factor (HSF)-1 pathway required for Caenorhabditis elegans immunity.
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HSF-1 and 90-kDa heat shock proteins required for immunity
"Heat-shock transcription factor (HSF)-1 pathway required for Caenorhabditis elegans immunity."
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HSP-90 participates in defense against Gram-negative bacteria
"Heat-shock transcription factor (HSF)-1 pathway required for Caenorhabditis elegans immunity."
Cloning, expression and characterisation of FKB-6, the sole large TPR-containing immunophilin from C. elegans.
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FKB-6 TPR domain binds DAF-21 MEEVD motif
"Cloning, expression and characterisation of FKB-6, the sole large TPR-containing immunophilin from C. elegans."
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Interaction similar to human FKBP-Hsp90 interaction
"Cloning, expression and characterisation of FKB-6, the sole large TPR-containing immunophilin from C. elegans."
C. elegans STI-1, the homolog of Sti1/Hop, is involved in aging and stress response.
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STI-1/Hop binds both HSP70 and HSP90 homologs
"C. elegans STI-1, the homolog of Sti1/Hop, is involved in aging and stress response."
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STI-1 functions as HSP90 co-chaperone
"C. elegans STI-1, the homolog of Sti1/Hop, is involved in aging and stress response."
The non-canonical Hop protein from Caenorhabditis elegans exerts essential functions and forms binary complexes with either Hsc70 or Hsp90.
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CeHop binds Hsp90 with high affinity
"The non-canonical Hop protein from Caenorhabditis elegans exerts essential functions and forms binary complexes with either Hsc70 or Hsp90."
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CeHop inhibits Hsp90 ATPase activity
"The non-canonical Hop protein from Caenorhabditis elegans exerts essential functions and forms binary complexes with either Hsc70 or Hsp90."
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Direct measurement of HSP-90 ATPase activity
"The non-canonical Hop protein from Caenorhabditis elegans exerts essential functions and forms binary complexes with either Hsc70 or Hsp90."
Cdc37-Hsp90 complexes are responsive to nucleotide-induced conformational changes and binding of further cofactors.
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CDC-37 binds HSP-90 and inhibits ATPase activity
"Cdc37-Hsp90 complexes are responsive to nucleotide-induced conformational changes and binding of further cofactors."
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Competitive and cooperative interactions between co-chaperones
"Cdc37-Hsp90 complexes are responsive to nucleotide-induced conformational changes and binding of further cofactors."
An analysis of the Caenorhabditis elegans lipid raft proteome using geLC-MS/MS.
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Proteomic survey of the C. elegans lipid raft fraction (44 proteins by geLC-MS/MS); the abstract does not name individual proteins, so HSP-90's presence rests on the GOA HDA curation of the full text
"A total of 44 proteins were identified from the lipid raft fraction using geLC-MS/MS"
Downregulation of the Hsp90 system causes defects in muscle cells of Caenorhabditis elegans.
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DAF-21 depletion causes muscle defects and reduced motility
"Downregulation of the Hsp90 system causes defects in muscle cells of Caenorhabditis elegans."
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MYO-3 myosin aggregates when DAF-21 is depleted
"Downregulation of the Hsp90 system causes defects in muscle cells of Caenorhabditis elegans."
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YFP-DAF-21 localizes to I-band and M-line in muscle
"Downregulation of the Hsp90 system causes defects in muscle cells of Caenorhabditis elegans."
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HSP-90 required for muscle maintenance
"Downregulation of the Hsp90 system causes defects in muscle cells of Caenorhabditis elegans."
The myosin chaperone UNC-45 is organized in tandem modules to support myofilament formation in C. elegans.
Yes-associated protein homolog, YAP-1, is involved in the thermotolerance and aging in the nematode Caenorhabditis elegans.
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DAF-21 knockdown blocks YAP-1 nuclear export after heat shock
"Yes-associated protein homolog, YAP-1, is involved in the thermotolerance and aging in the nematode Caenorhabditis elegans."
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HSP-90 regulates YAP-1 subcellular localization during stress recovery
"Yes-associated protein homolog, YAP-1, is involved in the thermotolerance and aging in the nematode Caenorhabditis elegans."
Regulation of organismal proteostasis by transcellular chaperone signaling.
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HSP-90 expression in one tissue protects distant tissues from proteotoxic stress
"Regulation of organismal proteostasis by transcellular chaperone signaling."
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Transcellular chaperone signaling requires PHA-4 transcription factor
"Regulation of organismal proteostasis by transcellular chaperone signaling."
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HSP-90 overexpression suppresses amyloid protein misfolding
"Regulation of organismal proteostasis by transcellular chaperone signaling."
The EBAX-type Cullin-RING E3 ligase and Hsp90 guard the protein quality of the SAX-3/Robo receptor in developing neurons.
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EBAX-1 binds DAF-21/Hsp90
"The EBAX-type Cullin-RING E3 ligase and Hsp90 guard the protein quality of the SAX-3/Robo receptor in developing neurons."
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DAF-21 and EBAX-1 collaboratively regulate SAX-3/Robo receptor quality
"The EBAX-type Cullin-RING E3 ligase and Hsp90 guard the protein quality of the SAX-3/Robo receptor in developing neurons."
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HSP-90 participates in triage protein quality control in neurons
"The EBAX-type Cullin-RING E3 ligase and Hsp90 guard the protein quality of the SAX-3/Robo receptor in developing neurons."
The activity of protein phosphatase 5 towards native clients is modulated by the middle- and C-terminal domains of Hsp90.
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HSP-90 forms homodimers
"The activity of protein phosphatase 5 towards native clients is modulated by the middle- and C-terminal domains of Hsp90."
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HSP-90 binds PPH-5 and activates its phosphatase activity
"The activity of protein phosphatase 5 towards native clients is modulated by the middle- and C-terminal domains of Hsp90."
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HSP-90 binds glucocorticoid receptor
"The activity of protein phosphatase 5 towards native clients is modulated by the middle- and C-terminal domains of Hsp90."
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Structural analysis of HSP-90/PPH-5 complex
"The activity of protein phosphatase 5 towards native clients is modulated by the middle- and C-terminal domains of Hsp90."
A PQM-1-Mediated Response Triggers Transcellular Chaperone Signaling and Regulates Organismal Proteostasis.
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HSP-90 is induced by PQM-1 during stress
"A PQM-1-Mediated Response Triggers Transcellular Chaperone Signaling and Regulates Organismal Proteostasis."
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HSP-90 maintains proteostasis and prevents protein misfolding
"A PQM-1-Mediated Response Triggers Transcellular Chaperone Signaling and Regulates Organismal Proteostasis."
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Heat stress induces hsp-90 expression
"A PQM-1-Mediated Response Triggers Transcellular Chaperone Signaling and Regulates Organismal Proteostasis."
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PQM-1 regulates heat-inducible hsp-90 expression
"A PQM-1-Mediated Response Triggers Transcellular Chaperone Signaling and Regulates Organismal Proteostasis."
Deep research report on hsp-90