Human chromosome 7: DNA sequence and biology.
Glycyl tRNA synthetase mutations in Charcot-Marie-Tooth disease type 2D and distal spinal muscular atrophy type V.
The DNA sequence of human chromosome 7.
Proteomic characterization of the human centrosome by protein correlation profiling.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Functional analyses of glycyl-tRNA synthetase mutations suggest a key role for tRNA-charging enzymes in peripheral axons.
Severe childhood SMA and axonal CMT due to anticodon binding domain mutations in the GARS gene.
Cytoplasmic and mitochondrial protein translation in axonal and dendritic terminal arborization.
Crystal structure of human wildtype and S581L-mutant glycyl-tRNA synthetase, an enzyme underlying distal spinal muscular atrophy.
Long-range structural effects of a Charcot-Marie-Tooth disease-causing mutation in human glycyl-tRNA synthetase.
Charcot-Marie-Tooth disease-associated mutant tRNA synthetases linked to altered dimer interface and neurite distribution defect.
Further evidence for genetic heterogeneity of distal HMN type V, CMT2 with predominant hand involvement and Silver syndrome.
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Crystal structures and biochemical analyses suggest a unique mechanism and role for human glycyl-tRNA synthetase in Ap4A homeostasis.
Charcot-Marie-Tooth disease type 2D with a novel glycyl-tRNA synthetase gene (GARS) mutation.
Initial characterization of the human central proteome.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
Two novel mutations of GARS in Korean families with distal hereditary motor neuropathy type V.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
Application of whole exome sequencing in undiagnosed inherited polyneuropathies.
Whole-exome sequencing in patients with inherited neuropathies: outcome and challenges.
Cocrystal structures of glycyl-tRNA synthetase in complex with tRNA suggest multiple conformational states in glycylation.
Impaired function is a common feature of neuropathy-associated glycyl-tRNA synthetase mutations.
N-terminome analysis of the human mitochondrial proteome.
Two Novel De Novo GARS Mutations Cause Early-Onset Axonal Charcot-Marie-Tooth Disease.
Elaborate uORF/IRES features control expression and localization of human glycyl-tRNA synthetase.
CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase.
Corrigendum: CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase.
Large Conformational Changes of Insertion 3 in Human Glycyl-tRNA Synthetase (hGlyRS) during Catalysis.
Crystal Structure of the Wild-Type Human GlyRS Bound with tRNA(Gly) in a Productive Conformation.
Compound heterozygous mutations in glycyl-tRNA synthetase (GARS) cause mitochondrial respiratory chain dysfunction.
Compound heterozygosity for loss-of-function GARS variants results in a multisystem developmental syndrome that includes severe growth retardation.
A novel mutation in the GARS gene in a Malian family with Charcot-Marie-Tooth disease.
GARS-related disease in infantile spinal muscular atrophy: Implications for diagnosis and treatment.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
Cloning, sequencing and bacterial expression of human glycine tRNA synthetase.
Primary structure and functional expression of human Glycyl-tRNA synthetase, an autoantigen in myositis.
Human glycyl-tRNA synthetase. Wide divergence of primary structure from bacterial counterpart and species-specific aminoacylation.
Purification of storage granule protein-23. A novel protein identified by phage display technology and interaction with type I plasminogen activator inhibitor.
Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic Gene Ontology annotation based on Rhea mapping
Combined Automated Annotation using Multiple IEA Methods
Cytosolic tRNA aminoacylation
Mitochondrial tRNA aminoacylation
glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate
glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate
Glycine--tRNA ligase, cytoplasmic/mitochondrial (GARS1)
Historical A61 sequence versus current mouse Gars1