Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Control of mitochondrial morphology by a human mitofusin.
Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis.
Dysregulation of HSG triggers vascular proliferative disorders.
MARCH-V is a novel mitofusin 2- and Drp1-binding protein able to change mitochondrial morphology.
Identification of a novel mitochondrial complex containing mitofusin 2 and stomatin-like protein 2.
Mitofusin 2 tethers endoplasmic reticulum to mitochondria.
Phenotypic spectrum of MFN2 mutations in the Spanish population.
Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy.
Autophagosomes form at ER-mitochondria contact sites.
PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria.
Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission.
Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily.
IHG-1 increases mitochondrial fusion and bioenergetic function.
Regulation of mitochondrial morphology and function by stearoylation of TFR1.
SAMM50 Affects Mitochondrial Morphology through the Association of Drp1 in Mammalian Cells.
Upregulated miR-17 Regulates Hypoxia-Mediated Human Pulmonary Artery Smooth Muscle Cell Proliferation and Apoptosis by Targeting Mitofusin 2.
MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion.
Architecture of the human interactome defines protein communities and disease networks.
Mfn2 deletion in brown adipose tissue protects from insulin resistance and impairs thermogenesis.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
TRABD modulates mitochondrial homeostasis and tissue integrity.
p62 links damaged mitochondria to LC3
LC3 binds the autophagosome membrane Atg5-Atg12 complex
p62 binds ubiquitinated mitochondrial substrates
RHOT2 binds effectors at the mitochondrial outer membrane
OPTN, TBK1 bind ubiquitinated MOM proteins
MAP1LC3B binds p-S-OPTN bound to Ub-mitochondria
TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins
p-S-TBK1 phosphorylates OPTN
PRKN ubiquitinates MOM substrates
PINK1 phosphorylates Ub on MOM proteins
PRKN binds p-S-Ub:MOM proteins
PINK1 phosphorylates PRKN at S65
Mitofusins trans-interact linking mitochondria prior to fusion