Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Gene Ontology annotation of human sequence-specific DNA binding transcription factors (DbTFs) based on the TFClass database

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress.

ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1.

ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs.

Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response.

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor.

A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6.

hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria.

Opposing roles for ATF6alpha and ATF6beta in endoplasmic reticulum stress response gene induction.

CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P.

Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response.

Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1.

The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis.

Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis.

Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays.

The unfolded protein response: integrating stress signals through the stress sensor IRE1α.

A thrombospondin-dependent pathway for a protective ER stress response.

Networks of bZIP protein-protein interactions diversified over a billion years of evolution.

ATF6 upregulates XBP1S and inhibits ER stress-mediated apoptosis in osteoarthritis cartilage.

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

Mutations in the unfolded protein response regulator ATF6 cause the cone dysfunction disorder achromatopsia.

Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance.

Impact of cytosine methylation on DNA binding specificities of human transcription factors.

ORMDL3 Facilitates the Survival of Splenic B Cells via an ATF6α-Endoplasmic Reticulum Stress-Beclin1 Autophagy Regulatory Pathway.

Sledgehammer to Scalpel: Broad Challenges to the Heart and Other Tissues Yield Specific Cellular Responses via Transcriptional Regulation of the ER-Stress Master Regulator ATF6α.

Interaction of ATF6 and serum response factor.

Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors.

ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus

MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha)

ATF6:HSPA5 (ATF6-alpha:BiP) dissociates and HSPA5 binds unfolded protein

ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi

MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)

IFI6 binds HSPA5