Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniPathway vocabulary mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
The sulfite oxidase Shopper controls neuronal activity by regulating glutamate homeostasis in Drosophila ensheathing glia.
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Shopper is a mitochondrial sulfite oxidase required in ensheathing glia; mutants have reduced SO activity, elevated sulfite and altered glutamate homeostasis affecting locomotion.
"In summary, these results demonstrate that the sulfite oxidase Shopper acts in ensheathing glial mitochondria to control larval locomotion."
Identifying potential dietary treatments for inherited metabolic disorders using Drosophila nutrigenomics.
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shop mutants model isolated sulfite oxidase deficiency; dietary cysteine depletion rescues development and survival.
"We show that dietary cysteine depletion normalizes their metabolic profile and rescues development, neurophysiology, behavior, and lifelong fly survival"