Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Hippocampal abnormalities and enhanced excitability in a murine model of human lissencephaly.
The LIS1-related NUDF protein of Aspergillus nidulans interacts with the coiled-coil domain of the NUDE/RO11 protein.
A role for the lissencephaly gene LIS1 in mitosis and cytoplasmic dynein function.
LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome.
Role of dynein, dynactin, and CLIP-170 interactions in LIS1 kinetochore function.
LIS1, CLIP-170's key to the dynein/dynactin pathway.
Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase.
A mammalian NudC-like protein essential for dynein stability and cell viability.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
NudC-like protein 2 regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90.
Systematic analysis of human protein complexes identifies chromosome segregation proteins.
Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.
Linking cytoplasmic dynein and transport of Rab8 vesicles to the midbody during cytokinesis by the doublecortin domain-containing 5 protein.
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Architecture of the human interactome defines protein communities and disease networks.
Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With Neurodevelopmental Disorders.
HENA, heterogeneous network-based data set for Alzheimer's disease.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Structures of human dynein in complex with the lissencephaly 1 protein, LIS1.
Molecular mechanism of dynein-dynactin complex assembly by LIS1.
Multimodal cell maps as a foundation for structural and functional genomics.
Miller-Dieker lissencephaly gene encodes a subunit of brain platelet-activating factor acetylhydrolase [corrected].
Point mutations and an intragenic deletion in LIS1, the lissencephaly causative gene in isolated lissencephaly sequence and Miller-Dieker syndrome.
MAD2 converted to an inhibitory state via interaction with Mad1
MAD2 associates with the Mad1 kinetochore complex
Release of activated MAD2 from kinetochores
Phosphorylation of cohesin by PLK1 at centromeres
PP2A-B56 dephosphorylates centromeric cohesin
ESPL1 (Separase) cleaves centromeric cohesin
Separation of sister chromatids
CDK1 phosphorylates CDCA5 (Sororin) at centromeres
AJUBA facilitates AURKA autophosphorylation
AJUBA binds centrosome-associated AURKA
AURKA phosphorylates PLK1
BORA binds PLK1 and AURKA
Kinetochore capture of astral microtubules
Plk1-mediated phosphorylation of Nlp
Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome
Loss of C-Nap-1 from centrosomes
Dissociation of Phospho-Nlp from the centrosome
Recruitment of Plk1 to centrosomes
Association of NuMA with microtubules
Recruitment of CDK11p58 to the centrosomes
Translocation of NuMA to the centrosomes
RAB3IP stimulates nucleotide exchange on RAB8A
C2CD3 binds the mother centriole
C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole
CP110 and CEP97 dissociate from the centriole
The distal appendage proteins recruit TTBK2
Recruitment of transition zone proteins
MARK4 binds ODF2 in the centriole
CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body
CDC42:GTP recruits DIAPH2-2 to kinetochores
AURKB phosphorylates DIAPH2-2 at kinetochores
Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2
PLA2s hydrolyze phospholipids at the Golgi membrane
RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex
TPX2 binds AURKA at centrosomes
TPX2 promotes AURKA autophosphorylation
EML4 recruits NUDC to mitotic spindle
LIS1 and NudE induce a persistent dynein force-producing state.
BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures.
Lis1 and doublecortin function with dynein to mediate coupling of the nucleus to the centrosome in neuronal migration.
LIS1 RNA interference blocks neural stem cell division, morphogenesis, and motility at multiple stages.
Distinct dose-dependent cortical neuronal migration and neurite extension defects in Lis1 and Ndel1 mutant mice.
A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system.
Ndel1 operates in a common pathway with LIS1 and cytoplasmic dynein to regulate cortical neuronal positioning.
UniProtKB record for human PAFAH1B1 (LIS1)
Falcon deep research report for PAFAH1B1