Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB.
Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB.
Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing.
Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins.
RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems.
INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation.
The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO.
TRIP6 is a RIP2-associated common signaling component of multiple NF-kappaB activation pathways.
Caspase recruitment domain protein 6 is a microtubule-interacting protein that positively modulates NF-kappaB activation.
Identification of a regulatory autophosphorylation site in the serine-threonine kinase RIP2.
Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa cell death.
Solution structure of NOD1 CARD and mutational analysis of its interaction with the CARD of downstream kinase RICK.
The NOD2-RICK complex signals from the plasma membrane.
Coordinated regulation of Toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chains.
Evaluation of Nod-like receptor (NLR) effector domain interactions.
XIAP mediates NOD signaling via interaction with RIP2.
Inhibition of RIP2's tyrosine kinase activity limits NOD2-driven cytokine responses.
Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1.
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.
cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4).
Cigarette smoke extract (CSE) delays NOD2 expression and affects NOD2/RIPK2 interactions in intestinal epithelial cells.
Activation of interferon regulatory factor 5 by site specific phosphorylation.
TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal degradation.
Identification and characterization of receptor-interacting protein 2 as a TNFR-associated factor 3 binding partner.
OTULIN restricts Met1-linked ubiquitination to control innate immune signaling.
Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling.
The molecular chaperone HSP70 binds to and stabilizes NOD2, an important protein involved in Crohn disease.
A proteome-scale map of the human interactome network.
Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins.
An inflammatory bowel disease-risk variant in INAVA decreases pattern recognition receptor-induced outcomes.
Structures of the inactive and active states of RIP2 kinase inform on the mechanism of activation.
E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP.
Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling.
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells.
Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling.
RIP2 filament formation is required for NOD2 dependent NF-κB signalling.
Structural basis of RIP2 activation and signaling.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
A reference map of the human binary protein interactome.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Valosin-containing protein-regulated endoplasmic reticulum stress causes NOD2-dependent inflammatory responses.
A central chaperone-like role for 14-3-3 proteins in human cells.
AI-guided pipeline for protein-protein interaction drug discovery identifies a SARS-CoV-2 inhibitor.
OTUD1 ameliorates cerebral ischemic injury through inhibiting inflammation by disrupting K63-linked deubiquitination of RIP2.
Understanding the molecular mechanism of pathogenic variants of BIR2 domain in XIAP-deficient inflammatory bowel disease.
RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase.
Identification of CARDIAK, a RIP-like kinase that associates with caspase-1.
Activated TAK1 mediates phosphorylation of the IKK Complex
Activated NOD oligomer recruites RIP2 (RICK)
p75NTR interacts with RIP2
Activated TAK1 phosphorylates MKK4/MKK7
activated human TAK1 phosphorylates MKK3/MKK6
TNFAIP3 (A20) deubiquitinates RIP2
RIP2 is K63 polyubiquitinated
K63 polyubiquitinated RIP2 associates with the TAK1 complex
RIP2 induces K63-linked ubiquitination of NEMO
CYLD deubiquitinates NEMO