Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniPathway vocabulary mapping
Combined Automated Annotation using Multiple IEA Methods
Characterization of a fungal maleylacetoacetate isomerase gene and identification of its human homologue.
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Recombinant MaiA has maleylacetoacetate isomerase activity; MaiA is a GST-family protein.
"The MaiA protein shows strong amino acid sequence identity to glutathione S-transferases and has MAAI activity when expressed in Escherichia coli."
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maiA disruption abolishes MAAI activity and growth on phenylalanine/phenylacetate and causes phenylalanine toxicity.
"maiA disruption prevents growth on phenylalanine (Phe) and phenylacetate and results in the absence of MAAI activity in vitro and Phe toxicity."
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maiA, fahA and hmgA are clustered and encode the enzymes of the common part of the Phe/phenylacetate pathways.
"maiA is clustered with fahA and hmgA, the genes encoding the two other enzymes of the common part of the Phe/phenylacetate pathways."
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maiA disruptants are succinylacetone-negative and accumulate 2,4-dioxohept-2-enoic acid isomers.
"Culture supernatants of an A. nidulans strain disrupted for maiA are succinylacetone-negative but specifically contain cis and/or trans isomers of 2, 4-dioxohept-2-enoic acid."
PAINT IBD nodes for PTHR42673
UniProt record for maiA (O43123)