Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
The role of FLT3 in haematopoietic malignancies.
Constitutive c-jun N-terminal kinase activity in acute myeloid leukemia derives from Flt3 and affects survival and proliferation.
Structural and functional alterations of FLT3 in acute myeloid leukemia.
Expanding the substantial interactome of NEMO using protein microarrays.
FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia.
SYK is a critical regulator of FLT3 in acute myeloid leukemia.
Src-like adaptor protein 2 (SLAP2) binds to and inhibits FLT3 signaling.
ABL2 suppresses FLT3-ITD-induced cell proliferation through negative regulation of AKT signaling.
STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells.
Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells.
PI3K-containing complexes phosphorylate PIP2 to PIP3
PI3K phosphorylates PIP2 to PIP3
PI3K inhibitors block PI3K catalytic activity
RAS GEFs promote RAS nucleotide exchange
FLT3LG dimer:FLT3 binds FLT3
FLT3LG dimer:FLT3 dimer autophosphorylates
Active FLT3:GRB2 binds SOS1
SOS1-mediated nucleotide exchange of RAS downstream of FLT3
Constitutive phosphorylation of FLT3 mutants
Ligand-independent dimerization of FLT3 mutants
FLT3 mutant dimers bind GRB2
FLT3 mutant dimers:GRB2 bind SOS1
FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS
FLT3 mutants:GRB2 bind GAB2
FLT3 mutants phosphorylate GAB2
FLT3 ITD mutants phosphorylate STAT5
FLT3 ITD mutants bind STAT5 through GAB2:PTPN11
FLT3 mutants:GRB2:p-Y-GAB2 binds PTPN11
PTPN11:p-STAT5 dissociates from mutant FLT3
p-STAT5 dissociates from mutant FLT3
Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
FLT3 mutants recruit PIK3CA through PIK3R1
PTPRJ dephosphorylates active FLT3
Active FLT3 phosphorylates CDKN1B
FLT mutants bind type I TKIs
FLT mutants bind type II TKIs
KW2449-resistant FLT3 mutants don't bind KW2449
semaxanib-resistant FLT3 mutants don't bind semaxanib<br>
crenolanib-resistant FLT3 mutants don't bind crenolanib
gilteritinib-resistant FLT3 mutants don't bind gilteritinib
lestaurtinib-resistant FLT3 mutants don't bind lestaurtinib
midostaurin-resistant FLT3 mutants don't bind midostaurin
pexidartinib-resistant FLT3 mutants don't bind pexidartinib
ponatinib-resistant FLT3 mutants don't bind ponatinib
quizartinib-resistant FLT3 mutants don't bind quizartinib
sorafenib-resistant FLT3 mutants don't bind sorafenib
sunitinib-resistant FLT3 mutants don't bind sunitinib
tandutinib-resistant FLT3 mutants don't bind tandutinib
linafinib-resistant FLT3 mutants don't bind linifanib
tamatinib-resistant FLT3 mutants don't bind tamatinib
Active FLT3 binds to ABL2
Active FLT3 binds to GRAP2
Active FLT3 binds to GRB10
Active FLT3 binds to SH2B3
Active FLT3 binds to SLA2
Active FLT3 binds to SOCS2
Active FLT3 binds to SOCS6
Active FLT3:p-Y-GRB10 binds PIK3R1
FLT3 phosphorylates GRB10
Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
CBL mutants don't ubiquitinate FLT3
Internalization of ubiquitinated FLT3