Falcon deep research report for ATG7
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Falcon supports ATG7 as the E1-like activating enzyme for both Atg12 and Atg8 ubiquitin-like conjugation systems in yeast autophagy.
"Atg7 is the E1 enzyme for the autophagy conjugation machinery. It activates Atg12 and also functions as the E1 for Atg8 in the Atg8-PE lipidation pathway."
Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Apg7p/Cvt2p is required for the cytoplasm-to-vacuole targeting, macroautophagy, and peroxisome degradation pathways.
Apg7p/Cvt2p: A novel protein-activating enzyme essential for autophagy.
A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae.
The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway.
A ubiquitin-like system mediates protein lipidation.
The carboxyl terminal 17 amino acids within Apg7 are essential for Apg8 lipidation, but not for Apg12 conjugation.
The proteome of Saccharomyces cerevisiae mitochondria.
In vivo and in vitro reconstitution of Atg8 conjugation essential for autophagy.
Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics.
Localization of autophagy-related proteins in yeast using a versatile plasmid-based resource of fluorescent protein fusions.
Piecemeal microautophagy of the nucleus requires the core macroautophagy genes.
High-quality binary protein interaction map of the yeast interactome network.
Mutation at the cargo-receptor binding site of Atg8 also affects its general autophagy regulation function.
A genomic screen for yeast mutants defective in selective mitochondria autophagy.
Insights into noncanonical E1 enzyme activation from the structure of autophagic E1 Atg7 with Atg8.
A late form of nucleophagy in Saccharomyces cerevisiae.
Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7-Atg3 and Atg7-Atg10 structures.
The role of autophagy in genome stability through suppression of abnormal mitosis under starvation.
Autophagic clearance of polyQ proteins mediated by ubiquitin-Atg8 adaptors of the conserved CUET protein family.
One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy.
The cellular economy of the Saccharomyces cerevisiae zinc proteome.