The review and source guide distinguish current judgments from the dated originals and prior review in the compact archive. Exact excerpt offsets and source grades are in source evidence.
PMID:20593814(https://pubmed.ncbi.nlm.nih.gov/20593814/), selected Methods/Results: long/short human reagents contain C154A/C165A despite being called wild type. Oxygen, cytochrome-c and DTT assays have distinct scope; no natural-product-specific kinetic assignment follows automatically.
PMID:22224850(https://pubmed.ncbi.nlm.nih.gov/22224850/), all four original main-text pages/captions: human 65–205 retains C71/C74; 81–205 lacks that distal shuttle. Principal reconstitution measures cytochrome-c reduction; oxygen/small-substrate discussion cites earlier work. Supplementary methods were not inspected.
PMID:21383138(https://pubmed.ncbi.nlm.nih.gov/21383138/), selected genuine PMC Results/Methods: human recognition/redox experiments use C154A/C165A long and C74A/C85A short backgrounds. Yeast Erv1 import tests are separate. The normal cache omits these sections despite its full-text flag.
PMID:23676665(https://pubmed.ncbi.nlm.nih.gov/23676665/), selected human-cell Results/Methods and Figure4 caption: association, substrate competition and coupled oxidation/import support the pathway. Main text reports mitochondrial ALR; supplemental localization images and construct sequences remain uninspected. No figure pixels or SI were read for these studies.
| Raw context | Partner | Actual inspected support | Interpretation limit |
|---|---|---|---|
| 0 | BNIPL / Q7Z465 | PMID12681488 full abstract: Y2H, pull-down, co-IP | Full methods/product mapping unavailable; tentative bridge model |
| 1 | CHCHD4 / Q8N4Q1 | PMID23676665 selected original human-cell association | Partner folding function is not transferred to GFER |
| 2 | PLEKHF2 / Q9H8W4 | PMID25416956 original sheet2G row1933, GeneIDs2671/79666, two screens; three IntAct rows | Positive pair does not establish GFER trafficking |
| 3 | nsp10 / P0DTD1-PRO_0000449628 | PMID32353859 source-specific IntAct pull-down record | Association need not be binary; original target table uninspected |
| 4 | nsp10 / P0DTD1-PRO_0000449628 | PMID33060197 source-specific IntAct pull-down record | No infected-cell mechanism inferred |
| 5 | nsp10 / P0DTD1-PRO_0000449628 | PMID36217030 original Table1, sheetS1 row107: nsp10/Y2H/GeneID2671/GFER | Direct screen pair, distinct from the pull-down records |
The processed viral partner is nsp10, residues4254–4392, not every enzyme in the polyprotein. Its stimulation of other enzymes does not make nsp10 their catalyst. All six positive interactions are preserved; generic-label removals do not reject them.
CHCHD4's reviewed official FUNCTION, accession-relative /comments/0/texts/0/value, states: “Functions as a chaperone”. Its complete sibling /comments/0/texts/0/evidences array is retained in source evidence, with the original response hash/pointer. This establishes partner class; selected PMID23676665 supplies the interaction evidence. The surrounding paragraph's other citations were not all independently read.
MitoCoP, PMID:34800366, original TableS1 A row463/B row417: group5152 includes P55789 and P55789-2, with Class1 subtractive/importomics and Cluster1 spatial support. This is experimental inclusion, but neither unique-product nor IMS resolution.
HPA metadata reports enhanced mitochondrial and cytosolic staining; mitochondrial examples include HPA041227/U2OS and HPA063553/A-549/MCF-7. Image pixels were not examined. UniProt P55789 assigns long-product IMS and short-product cytoplasmic/secreted pools; this does not manufacture isoform-specific GOA fields or a newly verified secretion assay.
Rat liver regeneration is within liver development: GO:0097421 is_a GO:0001889. PMID:24880092(https://pubmed.ncbi.nlm.nih.gov/24880092/) abstract reports reduced proliferation plus increased apoptosis after rat knockdown; PMID:8058770(https://pubmed.ncbi.nlm.nih.gov/8058770/) abstract reports positive recombinant rat125-residue ALR in a canine hepatotrophic assay. Full protocols remain unavailable. PMID:7708779(https://pubmed.ncbi.nlm.nih.gov/7708779/) is the verified linked correction; its contents are unknown. The actual Tetrapoda IBD remains valid. The unresolved issue is regenerative participation versus general survival dependence, not adulthood, donor count or lack of direct human testing.
PMID:19397338(https://pubmed.ncbi.nlm.nih.gov/19397338/): engineered human ALR oxidizes reduced MIA40 through the distal cysteine pair. Different substrates in the short/long cytochrome-c comparisons prevent a simple natural-product ranking.
PMID:19409522(https://pubmed.ncbi.nlm.nih.gov/19409522/): human wild-type cDNA improves patient-cell respiratory activity. This corroborates the mitochondrial relay but is not a direct import-rate or enzyme assay. Yeast variant tests are separate.