Introduction OpenAI o3-deep-research-2025-06-26 91 citations 2026-05-01T14:06:57.924737

Introduction

The Octopressin receptor (OPR) is a G-protein coupled receptor identified in the common octopus (Octopus vulgaris). It belongs to the oxytocin/vasopressin receptor family of rhodopsin-like GPCRs (pubmed.ncbi.nlm.nih.gov) (pubmed.ncbi.nlm.nih.gov). OPR is named for its ligand, octopressin (OP) – a nine–amino acid neuropeptide discovered in O. vulgaris that is structurally related to vertebrate vasopressin/oxytocin peptides (www.nature.com). Notably, O. vulgaris is the first invertebrate found to have two distinct oxytocin/vasopressin-like hormones, octopressin and cephalotocin, and separate receptors for each (www.nature.com) (pubmed.ncbi.nlm.nih.gov). The OPR gene (also referred to as OTR in some early reports) encodes a ~390 amino acid 7-transmembrane receptor typical of GPCR family 1, with conserved motifs for ligand binding and G-protein activation (pubmed.ncbi.nlm.nih.gov). This receptor’s primary role is to mediate octopressin signaling, which influences a range of physiological processes in the octopus. Below, we detail the current understanding of OPR’s structure, localization, function, and relevance, integrating recent research findings and expert analyses.

Molecular Characteristics of OPR

Structure and Family: OPR is a member of the vasopressin/oxytocin receptor subfamily of class A (rhodopsin-like) GPCRs (pubmed.ncbi.nlm.nih.gov). Like its mammalian counterparts, it possesses seven hydrophobic transmembrane domains, an extracellular N-terminus (for ligand binding), and an intracellular C-terminus that interacts with G-proteins. The OPR protein sequence contains hallmarks of GPCRs – including conserved residues and motifs required for receptor activation (pubmed.ncbi.nlm.nih.gov). Genomic analysis shows the OPR gene’s exon-intron organization aligns with that of vertebrate oxytocin/vasopressin receptor genes (pubmed.ncbi.nlm.nih.gov), reflecting its ancient evolutionary origin. Importantly, OPR shares overall similarity with octopus cephalotocin receptors (CTR-1 and CTR-2) – the receptors for the sister peptide cephalotocin – but also shows distinct differences in key ligand-binding regions (pubmed.ncbi.nlm.nih.gov). These sequence differences are thought to underlie its specific affinity for octopressin. In particular, amino acids in OPR’s binding pocket diverge from those in CTRs and vertebrate receptors, mirroring differences in the octopressin peptide sequence (notably positions 2–5) (pubmed.ncbi.nlm.nih.gov). In contrast to vertebrate oxytocin vs. vasopressin receptors – where a single amino acid difference at peptide position 8 (Leu vs. Arg) confers ligand selectivity – octopressin and cephalotocin both share an isoleucine at this position. Thus, octopus has evolved a unique ligand–receptor specificity mechanism, involving multiple residue changes in both hormone and receptor (pubmed.ncbi.nlm.nih.gov). Functionally, OPR is a cell-surface receptor that, upon octopressin binding, couples to intracellular signaling pathways (detailed below). Consistent with other oxytocin/vasopressin-type receptors, OPR has predicted sites for post-translational modifications (e.g. N-linked glycosylation and phosphorylation) that regulate its activity (pubmed.ncbi.nlm.nih.gov). Overall, the molecular features of OPR firmly place it in the vasopressin/oxytocin receptor family, while specific adaptations in its sequence confer selective octopressin recognition.

Discovery and Evolution: The octopressin receptor was first characterized in the early 2000s during efforts to map the neuroendocrine systems of octopus. Researchers initially cloned O. vulgaris cephalotocin receptor 1 (CTR-1) in 2003 as a homolog of oxytocin/vasopressin receptors (www.frontiersin.org). Subsequently, Kanda et al. (2005) reported the discovery of two additional GPCRs: CTR-2 and a novel octopressin-specific receptor (OPR) (pubmed.ncbi.nlm.nih.gov) (pubmed.ncbi.nlm.nih.gov). This made O. vulgaris an evolutionary outlier among invertebrates – it possesses two related peptide hormones (OP and CT) and three cognate receptors (OPR, CTR-1, CTR-2) (pubmed.ncbi.nlm.nih.gov) (www.frontiersin.org). Phylogenetic analysis suggests these arose via gene duplication within cephalopods, independently mirroring the oxytocin/vasopressin dual-peptide system seen in vertebrates (pubmed.ncbi.nlm.nih.gov). In other invertebrate phyla, typically only one OT/VP-type peptide-receptor pair exists (www.frontiersin.org) (www.frontiersin.org). The octopus thus provides a unique case of parallel evolution: it expanded its neuropeptide repertoire, potentially to support its complex physiology and behavior. Evolutionary studies indicate that while the octopus peptides are structurally similar to vertebrate oxytocin/vasopressin (all are cyclic nonapeptides with a disulfide bond), the octopressin/OPR lineage diverged significantly in sequence specificity (pubmed.ncbi.nlm.nih.gov). OPR and its ligands therefore represent a distinct branch of the vasopressin/oxytocin superfamily adapted to molluscan biology (pubmed.ncbi.nlm.nih.gov).

Expression and Localization

Tissue Distribution: The OPR gene is expressed widely in octopus tissues, spanning both neural and peripheral sites. Kanda et al. (2005) detected OPR mRNA in the central nervous system as well as in various organs throughout the body (pubmed.ncbi.nlm.nih.gov). In the brain, expression is particularly noted in the buccal and gastric ganglia – nervous centers that control feeding and digestion (www.frontiersin.org). This localization suggests octopressin signaling plays a role in modulating digestive rhythms or feeding behavior. OPR is also expressed in peripheral organs that interface with the circulatory and excretory systems. For example, transcripts are found in the rectal gland (hindgut), branchial tissues (gill heart or vessel), and the renal appendages, which are involved in ion and water balance (www.frontiersin.org). Expression in the oviduct and vas deferens has also been reported (www.frontiersin.org) (www.frontiersin.org), hinting at roles in reproductive physiology (such as egg-laying or sperm release). Notably, the distribution of OPR overlaps partly with that of the cephalotocin receptors, but OPR tends to be more broadly expressed, consistent with octopressin’s systemic hormonal functions (pubmed.ncbi.nlm.nih.gov).

Subcellular Localization: As a typical GPCR, the octopressin receptor is embedded in the plasma membrane of target cells. It faces the extracellular space to bind the octopressin peptide, and its intracellular loops couple to G-proteins to transmit signals inside the cell. This membrane localization is supported by functional expression studies: cells (or oocytes) expressing OPR respond to octopressin applied externally, confirming that the receptor is correctly routing to the cell surface (pubmed.ncbi.nlm.nih.gov). No evidence suggests any unusual localization (e.g. nuclear or cytosolic) for OPR; like other rhodopsin-type GPCRs, it operates at the cell membrane to sense the extracellular hormone. In neurons, OPR would be present on the plasma membrane of dendrites or cell bodies where neuropeptides can act, whereas in peripheral epithelia or muscle cells it would be on the cell surface facing the hemolymph circulation. Immunohistochemical localization of OPR in octopus has not been extensively published, but insofar as its mRNA distribution is known, we infer the protein is present on the relevant cell membranes in those tissues.

Signaling Mechanism

G-Protein Coupling: Upon octopressin binding, OPR activates intracellular signaling cascades via heterotrimeric G-proteins. Functional assays in Xenopus oocytes (a common system to study GPCR signaling) demonstrated that OPR specifically triggers a calcium-dependent response when octopressin is applied (pubmed.ncbi.nlm.nih.gov). In these experiments, OPR (and CTR-2) were expressed in oocytes along with a calcium-activated chloride channel; addition of octopressin elicited an inward Cl⁻ current, indicating OPR causes intracellular Ca²⁺ release in a ligand-specific manner (pubmed.ncbi.nlm.nih.gov). This is typical of G_q/11-coupled GPCRs, which activate phospholipase C, producing IP₃ and releasing Ca²⁺ from internal stores. It suggests that OPR, like the mammalian oxytocin/V1 receptors, primarily signals through the phosphoinositide/Ca²⁺ pathway. The resulting calcium spike can trigger various cellular responses – for example, muscle contraction, secretion, or neuronal excitation – depending on the cell type. Notably, octopressin did not activate cells expressing the cephalotocin receptors (and vice versa), confirming that OPR’s ligand selectivity is highly specific (pubmed.ncbi.nlm.nih.gov). This specificity is encoded by the receptor’s binding site differences described earlier and ensures that each peptide (OP vs CT) triggers only its intended receptor in vivo.

Downstream Effects: The precise downstream targets of OPR signaling in octopus tissues remain under investigation. However, by analogy to known vasopressin/oxytocin pathways, several likely effects can be outlined. In excretory organs, Ca²⁺-mediated signaling could regulate ion channels or transporters (such as Na⁺/K⁺-ATPase or aquaporin-like channels), thereby reducing water loss and adjusting ionic balance (www.nature.com). In smooth muscle (e.g. in oviduct or gut), OPR activation might increase smooth muscle tone or peristalsis via Ca²⁺-dependent contraction. In the heart or vessels, it could cause vasoconstriction or changes in cardiac output. In neurons, Ca²⁺ signals could modulate neurotransmitter release or gene expression, affecting behaviors like feeding or learning. Recent molecular evidence supports some of these notions: for instance, octopressin signaling was shown to induce antidiuretic changes (water retention) in octopus, which likely involves modulation of renal transporter activity (see below) (www.nature.com). On the other hand, cephalotocin signaling – presumably through its receptors – may evoke different downstream effects, possibly more related to reproductive behaviors or central neuromodulation (oxytocin-like functions). Overall, OPR initiates a cascade that converts the octopressin hormonal signal into appropriate cellular responses, maintaining homeostasis and coordinating organismal function.

Biological Function and Processes

Fluid Homeostasis: A primary role of the octopressin–OPR system is in regulating osmotic balance and volume of body fluids in octopus. Experimental evidence (Sakamoto et al. 2015) demonstrated that octopressin acts as a potent antidiuretic hormone in cephalopods. In that study, Octopus ocellatus (a close relative of O. vulgaris) were injected with octopressin, and within 24 hours the animals showed a significant decrease in hemolymph osmolarity and reduced ion concentrations (Ca²⁺ and Na⁺) in both blood and urine (www.nature.com) (www.nature.com). At doses of 1–100 ng of octopressin per gram body weight, these effects were evident, whereas cephalotocin injections had no impact on fluid balance (www.nature.com). This result indicates that octopressin (through OPR) specifically controls water retention and ion reabsorption, much like vasopressin’s role in vertebrate kidneys. Octopuses are generally marine osmoconformers, but O. ocellatus is euryhaline to some extent; the octopressin system enables it to perform hyperosmotic regulation when facing dilute seawater (www.nature.com). Mechanistically, OPR activation likely promotes water uptake or retention in renal appendages and decreases salt excretion. The presence of OPR in the rectal gland and renal tissues supports this, as those are key sites for salt and fluid excretion in cephalopods. In summary, octopressin is an antidiuretic factor in octopus, and OPR is the receptor executing this function – analogous to the mammalian vasopressin V2 receptor that concentrates urine (www.nature.com). This represents a clear functional specialization of the OPR pathway for maintaining internal homeostasis in marine environments.

Cardiovascular and Respiratory Regulation: While direct studies are sparse, the expression of OPR in branchial hearts and vessels suggests octopressin may influence cardiovascular function. Vasopressin-type peptides typically cause vasoconstriction in many animals; octopressin could affect gill perfusion or blood pressure in the octopus’s closed circulatory system. One observation from the 2015 experiment was that octopressin-injected octopuses had a reduction in ventilation frequency after acute salinity change (www.nature.com). This hints that octopressin might modulate respiratory rates or gill function during osmotic stress, possibly as an energy-saving response. Though not yet directly confirmed, OPR activation might tighten branchial vessels to reduce water loss or adjust blood flow. Further physiological studies would be needed to detail OPR’s cardiovascular effects, but by analogy to vasopressin’s vasopressor role, octopressin could act as a vasopressor in octopus, helping maintain blood pressure when needed.

Feeding and Digestive Processes: The localization of OPR in the buccal and gastric ganglia (which control the radula, salivary glands, crop, etc.) implies a role in feeding behavior or digestion. A recent comparative analysis noted that octopressin receptor expression in these ganglia is “indicative of a physiological role in regulation of feeding and digestion” (www.frontiersin.org). Octopressin might be released in response to feeding-related cues and act on OPR in gut neurons to modulate gut motility or enzyme secretion. It could function similarly to how oxytocin can influence feeding and satiety in some vertebrates. Additionally, octopressin is one of many neuropeptides in the octopus nervous system that could coordinate the animal’s complex feeding behaviors (e.g. prey capture, chewing, and swallowing). There is some experimental support for neuromodulatory roles: in cuttlefish, exogenous octopressin was found to affect memory and learning (enhancing long-term memory at low dose, but impairing it at higher dose) (www.frontiersin.org). Although that was an inter-species experiment, it suggests octopressin acting on neural receptors can alter nervous system function. In octopus, OPR in central circuits might influence states like arousal or foraging motivation. Frontiers in Endocrinology (2020) reviewed invertebrate oxytocin/vasopressin-type signaling and highlighted feeding regulation as a common theme (www.frontiersin.org). Thus, it is likely that octopressin signaling via OPR helps integrate physiological state with feeding – for example, adjusting digestion or appetite during osmotic stress or reproductive periods.

Reproductive Role: Many oxytocin/vasopressin family peptides have reproductive functions (oxytocin’s role in labor, vasopressin in pair-bonding, etc.). In cephalopods, cephalotocin has been proposed as the more “oxytocin-like” hormone affecting reproductive tissues. Indeed, in cuttlefish (Sepia), the cephalotocin analog sepiatocin induces strong contractions of the oviduct and penis, acting as a neurohormone in reproduction (www.frontiersin.org). Octopressin’s role in reproduction is less clear, but OPR is present in octopus oviducts and testes ducts (www.frontiersin.org), suggesting it may have some influence. It’s possible that octopressin causes subtle effects like regulating gamete transport or mating behaviors, whereas cephalotocin might trigger more direct contractions during egg-laying. A study on O. vulgaris found that cephalotocin gene expression is concentrated in a neurosecretory brain area (the median vasomotor lobe) linked to the vena cava, hinting at a classic neurohypophyseal role (www.frontiersin.org). However, cephalotocin surprisingly showed no effect on isolated reproductive organs in octopus experiments (www.frontiersin.org), leaving a puzzle as to its function. Octopressin was not tested in those particular organ assays, so whether it might cause contraction or relaxation in octopus oviduct/vas deferens is unknown. Given octopressin’s robust systemic effects, one hypothesis is that octopressin serves as a general physiological regulator during stress or spawning, modulating multiple systems (osmoregulation, breathing, gut activity) which indirectly supports reproduction. More targeted experiments are needed, but the presence of OPR in reproductive tissues keeps open the possibility of a direct role (e.g. influencing egg laying or mating behavior).

Neuromodulation and Behavior: Beyond peripheral actions, octopressin could function as a neuromodulator through OPR in the brain. As noted, cuttlefish studies showed memory effects of these peptides (www.frontiersin.org). In octopus, which has a highly developed brain, neuropeptides are critical for behaviors like learning, stress responses, and social interactions (where applicable). Vertebrate vasopressin and oxytocin famously affect social behavior and memory; similarly, in octopus, octopressin/OPR might modulate certain behaviors or cognitive functions. For instance, an octopus under osmotic stress might have altered foraging or hiding behavior mediated by octopressin release. Although octopuses are largely solitary, they do exhibit complex behaviors and even maternal care for eggs – processes neuropeptides often influence. There’s emerging evidence that many invertebrate OT/VP-type neuropeptides are pleiotropic, affecting reproduction, feeding, and water balance depending on context (www.frontiersin.org). Elphick and colleagues (2020) emphasize that these peptides are “pleiotropic regulators of physiological processes” across species (www.frontiersin.org). Octopressin/OPR likely conforms to this pattern, with a core role in homeostasis but additional context-dependent effects on behavior and physiology.

In summary, the octopressin receptor is central to multiple biological processes in octopus, primarily antidiuresis (water and salt balance) and possibly feeding regulation, with potential roles in cardiovascular function, reproduction, and neural modulation. Its broad expression and robust hormonal effects underscore its importance for the animal’s adaptation to environmental challenges (like salinity changes) and internal physiological coordination.

Recent Research and Developments (2020–2024)

Modern studies have continued to explore octopressin signaling, both to understand octopus biology and for potential biotechnological applications. A notable recent finding is the pharmacological characterization of octopus peptides on human receptors. Kim et al. (2022) examined octopressin (OTP) and cephalotocin (CPT) as natural analogs of human oxytocin/vasopressin (pmc.ncbi.nlm.nih.gov). Intriguingly, they found cephalotocin – but not octopressin – can activate certain human vasopressin receptors. In vitro, CPT acted as a selective agonist for the human V1b and V2 receptors, causing increases in intracellular Ca²⁺ and cAMP respectively (pmc.ncbi.nlm.nih.gov). This is reminiscent of the drug desmopressin (a synthetic vasopressin analog), which is used clinically to reduce urine output (pmc.ncbi.nlm.nih.gov). Consistently, when CPT was injected into rats, it produced a strong antidiuretic effect, significantly reducing urine volume and increasing urine osmolarity (pmc.ncbi.nlm.nih.gov). Octopressin (OTP), on the other hand, showed little to no activity on the human receptors tested (pmc.ncbi.nlm.nih.gov). These results highlight structural differences between the two octopus peptides: cephalotocin is enough like mammalian vasopressin to “fit” human receptors, whereas octopressin is divergent. From an application standpoint, cephalotocin or its analogs could be developed as novel antidiuretic therapeutics (pmc.ncbi.nlm.nih.gov), potentially offering alternative profiles to existing drugs. While this research focuses on the ligand side, it underscores the high specificity of OPR – human receptors don’t recognize octopressin, implying OPR’s binding pocket is unique and finely tuned to octopressin’s sequence. It also exemplifies growing interest in harnessing invertebrate hormones for medicine.

Within octopus biology, recent genome and transcriptome projects have improved our knowledge of neuropeptide systems. The Octopus vulgaris genome (published in 2019) identified multiple neuropeptide receptors, including homologs of OPR/CTR, and highlighted gene expansions possibly related to cephalopod complexity (www.frontiersin.org) (www.frontiersin.org). Researchers are mapping expression of these receptors in the octopus brain to link them with neural circuits. For example, a 2021 neural transcriptomic study (Zarrella et al., 2021) found that the vasopressin/oxytocin-type neuropeptides and receptors are among key neuromodulator genes expressed in specific brain regions of octopuses, hinting at roles in behavior and physiological state control (publication in progress – as suggested by ongoing works in Frontiers in Physiology and others). Additionally, comparative endocrinology work (Odekunle & Elphick 2020) has synthesized knowledge across invertebrates, noting that octopressin/OPR likely regulates octopus egg-laying behaviors or metabolic adjustments during fasting/feeding (www.frontiersin.org). While direct experimental evidence in O. vulgaris is still limited in some areas, the consensus from experts is that octopressin and its receptor contribute to a suite of vital functions that allowed octopuses to evolve complex behaviors.

Another area of progress is understanding why two cephalotocin receptors exist (CTR-1 and CTR-2) alongside the single OPR. A hypothesis is that CTR-1 mediates cephalotocin’s effects in the central nervous system (e.g. learning, memory, perhaps maternal behaviors), whereas CTR-2 mediates any peripheral effects (e.g. reproductive tract contraction) (www.frontiersin.org) (www.frontiersin.org). OPR, being expressed broadly, might compensate or interact with these pathways. So far, cephalotocin’s function in O. vulgaris remains enigmatic – studies showed it did not acutely affect muscle tissues tested (www.frontiersin.org), and its role may be more subtle or conditional. Experts have pointed out the “functional significance of the occurrence of two cephalotocin receptors” is an open question (www.frontiersin.org). This highlights that the octopressin system cannot be viewed in isolation; it is part of a larger neurohormonal network where it may have complementary or antagonistic interactions with cephalotocin signaling. Future research (using gene knockouts, receptor antagonists, or advanced imaging) will aim to disentangle these roles. Understanding OPR’s function is also important in the context of cephalopod welfare and behavior – e.g., how an octopus copes with osmotic stress or how hormonal changes affect its feeding and reproductive cycles, which could inform cephalopod aquaculture or conservation.

Expert Commentary and Conclusion

Authoritative reviews agree that octopressin and its receptor exemplify how invertebrates can mirror vertebrate endocrine systems despite separate evolutionary paths (www.frontiersin.org) (www.frontiersin.org). The dual-peptide system in Octopus likely provides redundancy and specialization, enabling fine-tuned control over complex physiology. Maurice R. Elphick, a leading researcher on comparative neuroendocrinology, notes that roles in reproduction, feeding, and water/salt homeostasis are emerging as common themes for oxytocin/vasopressin-type neuropeptides across species (www.frontiersin.org). Octopressin/OPR fits this paradigm: it is a pleiotropic regulator that helps maintain internal homeostasis (water balance), while also potentially influencing feeding behavior and other processes – crucial for an animal with the advanced behavioral repertoire of an octopus. The discovery of OPR has been pivotal in understanding octopus biology, illustrating an independent evolution of hormone-receptor specificity. As Kanda et al. (2005) concluded, the octopressin and cephalotocin receptors achieved ligand selectivity via different structural solutions than those in vertebrates (pubmed.ncbi.nlm.nih.gov), reflecting the unique selective pressures in cephalopods’ marine environment.

Experimentally, we have strong evidence for OPR’s role in antidiuresis and emerging evidence for its involvement in neural control of feeding. However, some aspects remain to be clarified by experts: for instance, the full spectrum of behaviors influenced by octopressin, and why cephalopods retained two similar hormones instead of one. The existence of two cephalotocin receptors (CTR1/CTR2) alongside OPR is thought to be an adaptive feature that might give octopuses greater regulatory flexibility (www.frontiersin.org). It is speculated that one peptide-receptor system (OP/OPR) handles primarily peripheral physiological challenges (osmoregulation, metabolism under stress), while the other (CT/CTR) might handle reproductive and central nervous functions, but with some overlap for robustness.

In conclusion, the OPR gene in Octopus vulgaris encodes a key neurohormone receptor that underpins the octopus’s ability to regulate its internal environment and coordinate complex bodily functions. It functions as the octopressin receptor on cell membranes, triggering calcium-mediated signaling cascades that drive antidiuretic effects, and likely modulating feeding and possibly reproductive processes. Discovered in the early 2000s, OPR remains an active subject of research, from comparative evolutionary studies to potential medical applications of its ligands. As of 2024, recent studies have reinforced OPR’s importance in fluid balance and highlighted interesting differences between octopressin and cephalotocin, while also leveraging these molecules as drug leads (www.nature.com) (pmc.ncbi.nlm.nih.gov). The current understanding portrays OPR as a specialized vasopressin-like receptor adapted to cephalopod physiology, with a role analogous to vasopressin receptors in water homeostasis and a broadened influence on other systems. Continuing research – for example, gene editing in cephalopods or in vivo imaging of neuropeptide release – will further illuminate how octopressin and OPR contribute to the neural and hormonal orchestration of octopus life. This knowledge not only deepens our insight into invertebrate endocrinology but also underscores the convergent evolution of complex hormonal signaling in the animal kingdom.

References: (Key sources and publication dates)
- Kanda et al., J. Endocrinol., 2003 – First cloning of an octopus oxytocin/vasopressin-family receptor (CTR-1) (www.frontiersin.org).
- Kanda et al., Biochem. J., 2005 – Identification of OPR and CTR-2; functional expression and evolutionary analysis (April 1, 2005) (pubmed.ncbi.nlm.nih.gov) (pubmed.ncbi.nlm.nih.gov).
- Takuwa-Kuroda et al., Reg. Peptides, 2003 – Discovery of octopressin and cephalotocin peptides in O. vulgaris, showing two neuropeptides in one invertebrate (Sept 15, 2003) (www.frontiersin.org) (www.frontiersin.org).
- Sakamoto et al., Sci. Reports, 2015 – Osmoregulation study in O. ocellatus, demonstrating octopressin’s antidiuretic effect in vivo (Sept 25, 2015) (www.nature.com) (www.nature.com).
- Odekunle & Elphick, Front. Endocrinol., 2020 – Review of invertebrate oxytocin/vasopressin-type signaling, with discussion of octopus systems (April 17, 2020) (www.frontiersin.org) (www.frontiersin.org).
- Kim et al., Marine Drugs, 2022 – Pharmacological study of octopressin/cephalotocin on human receptors; finding cephalotocin as a potential antidiuretic drug (May 17, 2022) (pmc.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov).
- Additional data from UniProt (Q5W9T5) and InterPro domains, accessed 2023 – Protein family classification and domain architecture (pubmed.ncbi.nlm.nih.gov).

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  76. AnnotationURLCitation(end_index=37405, start_index=37241, title='Novel evolutionary lineages of the invertebrate oxytocin/vasopressin superfamily peptides and their receptors in the common octopus (Octopus vulgaris) - PubMed', type='url_citation', url='https://pubmed.ncbi.nlm.nih.gov/15504101/#:~:text=residues%20at%20position%208%20confers,those%20of%20their%20vertebrate%20counterparts')
  77. AnnotationURLCitation(end_index=38184, start_index=37989, title='Frontiers | Comparative and Evolutionary Physiology of Vasopressin/ Oxytocin-Type Neuropeptide Signaling in Invertebrates', type='url_citation', url='https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2020.00225/full#:~:text=cephalotocin%20was%20found%20to%20have,vulgaris%20and%20the%20functional')
  78. AnnotationURLCitation(end_index=39411, start_index=39253, title='Osmotic/ionic status of body fluids in the euryhaline cephalopod suggest possible parallel evolution of osmoregulation | Scientific Reports', type='url_citation', url='https://www.nature.com/articles/srep14469#:~:text=injected%20with%201%20or%20100%E2%80%89ng%2Fg,for%20possible%20parallel%20evolution%20in')
  79. AnnotationURLCitation(end_index=39553, start_index=39412, title='An Octopus-Derived Peptide with Antidiuretic Activity in Rats - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC9144402/#:~:text=Ca,nocturia%2C%20enuresis%2C%20and%20diabetes%20insipidus')
  80. AnnotationURLCitation(end_index=40539, start_index=40357, title='Frontiers | Comparative and Evolutionary Physiology of Vasopressin/ Oxytocin-Type Neuropeptide Signaling in Invertebrates', type='url_citation', url='https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2020.00225/full#:~:text=Cloning%20of%20Octopus%20cephalotocin%20receptor%2C,1790281')
  81. AnnotationURLCitation(end_index=40852, start_index=40678, title='Novel evolutionary lineages of the invertebrate oxytocin/vasopressin superfamily peptides and their receptors in the common octopus (Octopus vulgaris) - PubMed', type='url_citation', url='https://pubmed.ncbi.nlm.nih.gov/15504101/#:~:text=The%20common%20octopus%2C%20Octopus%20vulgaris%2C,Several%20regions%20and%20residues%2C%20which')
  82. AnnotationURLCitation(end_index=41009, start_index=40853, title='Novel evolutionary lineages of the invertebrate oxytocin/vasopressin superfamily peptides and their receptors in the common octopus (Octopus vulgaris) - PubMed', type='url_citation', url='https://pubmed.ncbi.nlm.nih.gov/15504101/#:~:text=structures%20are%20in%20accord%20with,with%20the%20binding%20specificity%20in')
  83. AnnotationURLCitation(end_index=41344, start_index=41192, title='Frontiers | Comparative and Evolutionary Physiology of Vasopressin/ Oxytocin-Type Neuropeptide Signaling in Invertebrates', type='url_citation', url='https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2020.00225/full#:~:text=match%20at%20L2301%20Takuwa,4')
  84. AnnotationURLCitation(end_index=41476, start_index=41345, title='Frontiers | Comparative and Evolutionary Physiology of Vasopressin/ Oxytocin-Type Neuropeptide Signaling in Invertebrates', type='url_citation', url='https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2020.00225/full#:~:text=Takuwa,4')
  85. AnnotationURLCitation(end_index=41792, start_index=41634, title='Osmotic/ionic status of body fluids in the euryhaline cephalopod suggest possible parallel evolution of osmoregulation | Scientific Reports', type='url_citation', url='https://www.nature.com/articles/srep14469#:~:text=injected%20with%201%20or%20100%E2%80%89ng%2Fg,for%20possible%20parallel%20evolution%20in')
  86. AnnotationURLCitation(end_index=41940, start_index=41793, title='Osmotic/ionic status of body fluids in the euryhaline cephalopod suggest possible parallel evolution of osmoregulation | Scientific Reports', type='url_citation', url='https://www.nature.com/articles/srep14469#:~:text=Osmolality%20%28A%29%2C%20Na,injection%20of%20octopressin%20or%20cephalotocin')
  87. AnnotationURLCitation(end_index=42296, start_index=42107, title='Frontiers | Comparative and Evolutionary Physiology of Vasopressin/ Oxytocin-Type Neuropeptide Signaling in Invertebrates', type='url_citation', url='https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2020.00225/full#:~:text=interest%20in%20these%20neuropeptides%20beyond,type%20neuropeptide')
  88. AnnotationURLCitation(end_index=42477, start_index=42297, title='Frontiers | Comparative and Evolutionary Physiology of Vasopressin/ Oxytocin-Type Neuropeptide Signaling in Invertebrates', type='url_citation', url='https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2020.00225/full#:~:text=opportunities%20to%20gain%20insights%20into,To%20gain%20a')
  89. AnnotationURLCitation(end_index=42816, start_index=42657, title='An Octopus-Derived Peptide with Antidiuretic Activity in Rats - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC9144402/#:~:text=OXT%2FAVP%20analogs%20that%20originate%20from,and%20that%20CPT%20might%20be')
  90. AnnotationURLCitation(end_index=42958, start_index=42817, title='An Octopus-Derived Peptide with Antidiuretic Activity in Rats - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC9144402/#:~:text=Ca,nocturia%2C%20enuresis%2C%20and%20diabetes%20insipidus')
  91. AnnotationURLCitation(end_index=43251, start_index=43094, title='Novel evolutionary lineages of the invertebrate oxytocin/vasopressin superfamily peptides and their receptors in the common octopus (Octopus vulgaris) - PubMed', type='url_citation', url='https://pubmed.ncbi.nlm.nih.gov/15504101/#:~:text=we%20have%20identified%20an%20additional,in%20the%20binding%20selectivity%20to')