Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Automatic assignment of GO terms using logical inference, based on inter-ontology links
The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans.
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First identification of ZC376.7 (now ATFS-1) as the bZIP transcription factor mediating UPRmt
"The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans."
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HAF-1 is required for UPRmt signaling
"The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans."
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Nuclear localization of ATFS-1 depends on HAF-1 function during mitochondrial stress
"The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans."
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ClpP-mediated peptide generation contributes to UPRmt signaling
"The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans."
Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation.
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Established the mitochondrial import efficiency model for ATFS-1 regulation
"Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation."
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ATFS-1 has both MTS and NLS sequences
"Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation."
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Normally imported to mitochondria and degraded by Lon protease
"Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation."
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Mitochondrial stress reduces import, allowing nuclear translocation
"Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation."
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Cells monitor mitochondrial import efficiency via ATFS-1
"Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation."
Protective coupling of mitochondrial function and protein synthesis via the eIF2α kinase GCN-2.
Networks of bZIP protein-protein interactions diversified over a billion years of evolution.
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Large-scale bZIP dimerization study
"Networks of bZIP protein-protein interactions diversified over a billion years of evolution."
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ATFS-1 interacts with CEBP-2
"Networks of bZIP protein-protein interactions diversified over a billion years of evolution."
Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection.
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ATFS-1 induces innate immune genes during mitochondrial stress
"Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection."
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P. aeruginosa causes mitochondrial stress and UPRmt activation
"Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection."
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atfs-1 mutants are susceptible to P. aeruginosa
"Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection."
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atfs-1(et18) gain-of-function provides enhanced pathogen resistance
"Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection."
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Innate immune genes induced include abf-2, lys-2, clec-4, clec-65
"Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection."
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UPRmt can function independent of MAP and c-Jun kinase pathways
"Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection."
Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the UPR(mt).
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ATFS-1 binds promoters in both nuclear and mitochondrial genomes
"Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the UPR(mt)."
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Regulates mitochondrial chaperones, OXPHOS assembly factors, glycolysis genes
"Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the UPR(mt)."
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Required to limit OXPHOS transcript accumulation during stress
"Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the UPR(mt)."
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Balanced ATFS-1 accumulation in nucleus and mitochondria promotes OXPHOS recovery
"Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the UPR(mt)."
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Fine-tunes OXPHOS expression to match protein-folding capacity
"Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the UPR(mt)."
The Mitochondrial Unfolded Protein Response Protects against Anoxia in Caenorhabditis elegans.
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UPRmt activation protects against anoxia-reperfusion injury
"The Mitochondrial Unfolded Protein Response Protects against Anoxia in Caenorhabditis elegans."
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atfs-1 is necessary and sufficient for protection
"The Mitochondrial Unfolded Protein Response Protects against Anoxia in Caenorhabditis elegans."
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atfs-1(et15) gain-of-function mutants are protected from anoxia
"The Mitochondrial Unfolded Protein Response Protects against Anoxia in Caenorhabditis elegans."
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Protection can be cell-autonomous
"The Mitochondrial Unfolded Protein Response Protects against Anoxia in Caenorhabditis elegans."
The Mitochondrial Unfolded Protein Response Is Mediated Cell-Non-autonomously by Retromer-Dependent Wnt Signaling.
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UPRmt can be triggered cell-non-autonomously
"The Mitochondrial Unfolded Protein Response Is Mediated Cell-Non-autonomously by Retromer-Dependent Wnt Signaling."
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Retromer-dependent Wnt signaling propagates mitochondrial stress signals
"The Mitochondrial Unfolded Protein Response Is Mediated Cell-Non-autonomously by Retromer-Dependent Wnt Signaling."
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Neuronal mitochondrial stress induces UPRmt in peripheral tissues
"The Mitochondrial Unfolded Protein Response Is Mediated Cell-Non-autonomously by Retromer-Dependent Wnt Signaling."
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Wnt ligand EGL-20 is sufficient to induce cell-non-autonomous UPRmt
"The Mitochondrial Unfolded Protein Response Is Mediated Cell-Non-autonomously by Retromer-Dependent Wnt Signaling."
SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension.
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ATFS-1 is SUMOylated at K342
"SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension."
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ULP-4 desumoylates ATFS-1
"SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension."
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Desumoylation enhances ATFS-1 transcriptional activity
"SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension."
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K342R mutation abolishes sumoylation but does not affect nuclear localization
"SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension."
ATFS-1 translocates from the cytosol to the mitochondrial matrix
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Reactome pathway annotation for ATFS-1 mitochondrial import
"In unstressed cells, ATFS-1 is translocated from the cytosol to the mitochondrial matrix where it is constitutively degraded by the protease Lon-P"
ATFS-1 translocates from the cytosol to the nucleoplasm
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Reactome pathway annotation for ATFS-1 nuclear translocation during stress
"Upon mitochondrial stress that causes a reduction in mitochondrial import of proteins, less ATFS-1 is imported into mitochondria, ATFS-1 accumulates in the cytosol, and a greater amount of ATFS-1 is imported into the nucleus"
Deep research report on atfs-1