RPS3 notes

Falcon integration, 2026-05-12

• Falcon identifies the core function as the canonical 40S/uS3 ribosomal role: structural constituent of the cytosolic small ribosomal subunit supporting translation [file:human/RPS3/RPS3-deep-research-falcon.md "RPS3 is a core protein of the cytosolic small ribosomal subunit (40S) and therefore supports GO annotations centered on (i) structural constituent of ribosome, (ii) cytoplasmic translation, and (iii) localization to cytosolic ribosome / small ribosomal subunit / cytosol (cytoplasm)."].
• Human ribosome structural work supports the ribosome/small-subunit context PMID:23636399.
• Damaged-DNA binding and BER roles are real but secondary to the ribosomal function; hS3 binds AP DNA strongly PMID:14706345 and may influence repair at DNA damage sites PMID:15518571.
• Apoptosis annotations should be kept non-core because the evidence is context-dependent overexpression/cytokine treatment PMID:14988002.
• Falcon found no direct RPS3-specific support for stable mitochondrial inner membrane or ER localization in the retrieved corpus, so the automated mitochondrial inner membrane row was removed [file:human/RPS3/RPS3-deep-research-falcon.md "Mitochondrial inner membrane / ER: no direct, RPS3-specific evidence in the retrieved corpus supports stable mitochondrial inner membrane or ER localization; avoid those CC annotations without targeted localization data."].