Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Population of ATP synthase molecules in mitochondria is limited by available 6.8-kDa proteolipid protein (MLQ).
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MLQ knockdown depletes mitochondrial ATP synthase.
"Here, we show that MLQ-knockdown HeLa cells lose population of ATP synthase in mitochondria."
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MLQ knockdown lowers ATP synthesis and growth.
"As a consequence, the knockdown cells show low mitochondrial ATP synthesis activity, grow slowly in the normal medium, and are vulnerable to glucose deprivation."
Assembly of human mitochondrial ATP synthase through two separate intermediates, F1-c-ring and b-e-g complex.
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
Enzyme-bound ATP is released
ADP and Pi bind to ATPase
F1Fo ATP synthase dimerizes
Structure of the human ATP synthase.
UniProt entry P56378 (ATP68_HUMAN)
Affinage mechanistic annotation for ATP5MJ (human)