Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

PMID:10949025

Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1.

AVEN was identified by yeast two-hybrid screen for BCL-xL interactors
AVEN binds both BCL-xL and Apaf-1
AVEN interferes with Apaf-1 self-association
AVEN inhibits caspase proteolytic activation in cell-free extracts
AVEN suppresses apoptosis induced by Apaf-1 plus caspase-9
AVEN is broadly expressed and conserved in mammals
AVEN localizes to light membrane/vesicular fractions

Reactome:R-HSA-6805507

APAF1 binds AVEN

AVEN binding to APAF1 interferes with APAF1 self-association during apoptosome assembly
Anti-apoptotic function of AVEN may require proteolytic removal of inhibitory N-terminus

file:human/AVEN/AVEN-deep-research-falcon.md

Deep research synthesis for AVEN

AVEN binds and stabilizes BCL-xL, potentiating its anti-apoptotic function
Cathepsin D cleaves AVEN N-terminus at aa 144/145 and 196/197 to unleash anti-apoptotic activity
AVEN contains a predicted BH3-like motif (aa 141-153) for BCL-xL interaction
ATM phosphorylates AVEN at Ser135/Ser138 for G2/M checkpoint function
AVEN is overexpressed in acute leukemias with adverse outcomes