Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Basic-zipper-type transcription factor FlbB controls asexual development in Aspergillus nidulans.
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ΔflbB does not express brlA; FlbB is apical early and nuclear later; overexpression is aconidial.
"no brlA expression was detected in the flbB -null mutant, showing that FlbB is required, directly or indirectly, for proper brlA transcription regulation"
Aspergillus nidulans FlbE is an upstream developmental activator of conidiation functionally associated with the putative transcription factor FlbB.
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FlbB and FlbE colocalize at the hyphal tip (actin-dependent) and interact in vivo by BiFC.
"Moreover, bimolecular fluorescence studies show that they physically interact in vivo."
The bZIP-type transcription factor FlbB regulates distinct morphogenetic stages of colony formation in Aspergillus nidulans.
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FlbB localizes to tips of growing metulae; flbB mutants have branching and osmotic-autolysis defects.
"FlbB was located at the tip of growing metulae, following a similar pattern as described in vegetative hyphae."
The concerted action of bZip and cMyb transcription factors FlbB and FlbD induces brlA expression and asexual development in Aspergillus nidulans.
Elucidation of functional markers from Aspergillus nidulans developmental regulator FlbB and their phylogenetic distribution.
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An FlbB C382A point mutant is fluffy; 40 Pezizomycotina FlbB orthologs, including N. crassa NCU07379, share the H19 bZIP and a Yap1-like C-terminus.
"flbB-C382A exhibited a fluffy phenotype with sparse conidiation thus confirming that C382 is critical for FlbB function in Anidu."
Regulation of conidiation by light in Aspergillus nidulans.
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Light induction of brlA requires flbA-C, among other genes.
"We have found that light induction of brlA required the photoreceptor complex composed of a phytochrome FphA, and the white-collar homologs LreA and LreB, and the fluffy genes flbA-C."
Tip-to-nucleus migration dynamics of the asexual development regulator FlbB in vegetative cells.
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Tip localization needs Cys382 and the bZIP domain; FlbE binds the bZIP domain and confers transcriptional competence; a bipartite NLS mediates nuclear import.
"Tip localization of FlbB depends on Cys382 in the C-terminus and the bZIP DNA-binding domain in the N-terminus."
Beyond asexual development: modifications in the gene expression profile caused by the absence of the Aspergillus nidulans transcription factor FlbB.
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RNA-seq of ΔflbB confirms that FlbB activates flbD and brlA; it also represses the dba cluster and activates urdA.
"Results confirmed the activating role of FlbB on downstream regulators of conidiation such as flbD and brlA."
Developmental regulators FlbE/D orchestrate the polarity site-to-nucleus dynamics of the fungal bZIP transcription factor FlbB.
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FlbE drives acropetal transport of FlbB; dynein mediates its transport to nuclei; FlbD controls its nuclear accumulation; FlbB binds the brlA promoter (ChIP) only in the presence of FlbD.
"FlbD controls the nuclear accumulation of FlbB through a cMyb domain and a C-terminal LxxLL motif."
NCU07379 placement within PTHR40621:SF6 (MAFFT/NJ phylogeny)
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FlbB (C8VBM8) and NCU07379 form a clade with 100% bootstrap support, separate from the Yap1/NapA clade, within PTHR40621:SF6.
"NCU07379 groups with the FlbB clade. In the NJ tree, the clade"