Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
skn-1, a maternally expressed gene required to specify the fate of ventral blastomeres in the early C. elegans embryo.
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SKN-1 is required for mesendoderm specification
"skn-1, a maternally expressed gene required to specify the fate of ventral blastomeres in the early C. elegans embryo."
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SKN-1 specifies fate of ventral blastomeres
"skn-1, a maternally expressed gene required to specify the fate of ventral blastomeres in the early C. elegans embryo."
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Maternal contribution is essential for gut development
"skn-1, a maternally expressed gene required to specify the fate of ventral blastomeres in the early C. elegans embryo."
The maternal gene skn-1 encodes a protein that is distributed unequally in early C. elegans embryos.
Spatial and temporal controls target pal-1 blastomere-specification activity to a single blastomere lineage in C. elegans embryos.
SKN-1 domain folding and basic region monomer stabilization upon DNA binding.
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SKN-1 binds DNA as a monomer through unique mechanism
"SKN-1 domain folding and basic region monomer stabilization upon DNA binding."
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Skn domain structure and DNA-binding properties characterized
"SKN-1 domain folding and basic region monomer stabilization upon DNA binding."
A new DNA-binding motif in the Skn-1 binding domain-DNA complex.
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Crystal structure of SKN-1 DNA-binding domain
"A new DNA-binding motif in the Skn-1 binding domain-DNA complex."
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Novel fold with four-helix unit organizing DNA contacts
"A new DNA-binding motif in the Skn-1 binding domain-DNA complex."
SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response.
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SKN-1 regulates Phase II detoxification genes
"SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response."
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SKN-1 accumulates in intestinal nuclei upon oxidative stress
"SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response."
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skn-1 mutants are sensitive to oxidative stress
"SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response."
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skn-1 mutants have shortened lifespan
"SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response."
Genetic redundancy in endoderm specification within the genus Caenorhabditis.
The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response.
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PMK-1 phosphorylates SKN-1 at Ser-164 and Ser-430
"The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response."
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Phosphorylation promotes nuclear localization
"The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response."
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SKN-1 activates gcs-1 transcription
"The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response."
Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans.
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IIS kinases AKT-1/2 and SGK-1 phosphorylate SKN-1
"Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans."
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Reduced IIS leads to SKN-1 nuclear accumulation
"Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans."
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SKN-1 promotes longevity independently of DAF-16
"Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans."
The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans.
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WDR-23 targets SKN-1 for proteasomal degradation
"The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans."
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CUL4/DDB1 ubiquitin ligase complex controls SKN-1 levels
"The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans."
Life-span extension by dietary restriction is mediated by NLP-7 signaling and coelomocyte endocytosis in C. elegans.
Manipulation of behavioral decline in Caenorhabditis elegans with the Rag GTPase raga-1.
TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.
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TORC1 inhibition activates SKN-1
"TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO."
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SKN-1 required for rapamycin-mediated lifespan extension
"TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO."
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SKN-1 and DAF-16 have non-overlapping functions
"TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO."
Mitochondrial SKN-1/Nrf mediates a conserved starvation response.
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SKN-1 interacts with PGAM-5 and MXL-3
"Mitochondrial SKN-1/Nrf mediates a conserved starvation response."
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SKN-1 mediates metabolic adaptation to starvation
"Mitochondrial SKN-1/Nrf mediates a conserved starvation response."
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Mitochondrial localization of SKN-1 isoform
"Mitochondrial SKN-1/Nrf mediates a conserved starvation response."
The Nrf2/SKN-1-dependent glutathione S-transferase π homologue GST-1 inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of manganism.
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SKN-1 regulates GST-1 expression
"The Nrf2/SKN-1-dependent glutathione S-transferase π homologue GST-1 inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of manganism."
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SKN-1 protects against manganese toxicity
"The Nrf2/SKN-1-dependent glutathione S-transferase π homologue GST-1 inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of manganism."
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Phase II detoxification is neuroprotective
"The Nrf2/SKN-1-dependent glutathione S-transferase π homologue GST-1 inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of manganism."
Integration of the unfolded protein and oxidative stress responses through SKN-1/Nrf.
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SKN-1 integrates UPR and oxidative stress responses
"Integration of the unfolded protein and oxidative stress responses through SKN-1/Nrf."
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SKN-1 interacts with Hsp70/HSP-4
"Integration of the unfolded protein and oxidative stress responses through SKN-1/Nrf."
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ER localization of SKN-1A
"Integration of the unfolded protein and oxidative stress responses through SKN-1/Nrf."
Regulation of synaptic nlg-1/neuroligin abundance by the skn-1/Nrf stress response pathway protects against oxidative stress.
Investigating the role of RIO protein kinases in Caenorhabditis elegans.
Centrosome-Associated Degradation Limits β-Catenin Inheritance by Daughter Cells after Asymmetric Division.
The Developmental Intestinal Regulator ELT-2 Controls p38-Dependent Immune Responses in Adult C. elegans.
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SKN-1 regulates innate immunity genes
"The Developmental Intestinal Regulator ELT-2 Controls p38-Dependent Immune Responses in Adult C. elegans."
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Defense response to Gram-negative bacteria
"The Developmental Intestinal Regulator ELT-2 Controls p38-Dependent Immune Responses in Adult C. elegans."
SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans.
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Comprehensive review of SKN-1 functions
"SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans."
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SKN-1 regulates stress responses, metabolism, and aging
"SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans."
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Complex regulation by multiple signaling pathways
"SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans."
The Oxidative Stress Response in Caenorhabditis elegans Requires the GATA Transcription Factor ELT-3 and SKN-1/Nrf2.
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SKN-1 interacts with ELT-3 to activate gst-4
"The Oxidative Stress Response in Caenorhabditis elegans Requires the GATA Transcription Factor ELT-3 and SKN-1/Nrf2."
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BRAP-2 negatively regulates SKN-1 through p38 inhibition
"The Oxidative Stress Response in Caenorhabditis elegans Requires the GATA Transcription Factor ELT-3 and SKN-1/Nrf2."
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SKN-1 overexpression extends lifespan via ELT-3
"The Oxidative Stress Response in Caenorhabditis elegans Requires the GATA Transcription Factor ELT-3 and SKN-1/Nrf2."
Tribbles pseudokinase NIPI-3 regulates intestinal immunity in Caenorhabditis elegans by controlling SKN-1/Nrf activity.
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NIPI-3 positively regulates SKN-1 activity
"Tribbles pseudokinase NIPI-3 regulates intestinal immunity in Caenorhabditis elegans by controlling SKN-1/Nrf activity."
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SKN-1 nuclear translocation during pathogen infection
"Tribbles pseudokinase NIPI-3 regulates intestinal immunity in Caenorhabditis elegans by controlling SKN-1/Nrf activity."
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Defense response to P. aeruginosa and E. faecalis
"Tribbles pseudokinase NIPI-3 regulates intestinal immunity in Caenorhabditis elegans by controlling SKN-1/Nrf activity."
Deep research report on skn-1
OpenScientist hypothesis run: SKN-1 translation-regulation (GO:0006417) over-annotation
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Non-structural (domain/regulatory) analysis concluded that GO:0006417 (regulation of translation, IEA from UniProt keyword KW-0810) is an over-annotation; SKN-1 lacks any RNA-binding or translation-factor domain and acts only as a transcription factor, with the keyword conflating activation BY translation inhibition with direct translation regulation.
"The curation recommendation is to remove GO:0006417 from P34707 and to flag UniProtKB keyword KW-0810 for removal from this entry."