BABAM2 notes

2026-10-05 review (PAINT, affinage)

• BRE/BRCC45 is the UEV-domain adaptor of BRCA1-A and BRISC. It bridges BABAM1 to the rest of the complex PMID:21282113.
• REMOVE: peroxisome signal sequence receptor activity (TAS). PMID:11676476 Carrying a PTS1 does not make BRE a receptor.
• MODIFY the TNFRSF1A IPI to GO:0005164 and the FAS IPI to GO:0005123 (PMID:15465831). The TNF/apoptosis rows are non-core, and UniProt notes these effects may be indirect.
• Response to vitamin B6 is marked as an over-annotation (SHMT2 is the sensor). The IEP DNA damage response row is non-core.

2026-10-05 revision (reviewer round 1)

• Nucleus/nucleoplasm rows now quote UniProt's Nucleus line, with no unrelated paper quotes.
• NEW GO:0030674 adaptor activity (IDA, PMID:19261748) is the core MF of both complexes. It is supported by the BABAM1 bridging and by USP7 recruitment PMID:29416040.
• Fas: an earlier Y2H found no Fas binding (PMID:9737713), and the later PMID:15465831 reports binding. The MODIFY to GO:0005123 follows the later direct data, and the discrepancy is noted in the row.
• Signal transduction is marked as an over-annotation. GO:0044818 is accepted because it is a parent of the core GO:0007095.
• GOA has 70 lines. The two GO:0000152/IDA/PMID:14636569 lines differ only in assigned_by (ComplexPortal vs UniProt) and date, and the stub collapses them to one row; 69 rows were reviewed.