Gene Ontology annotation reference GO_REF:0000015

Annotation inferences using phylogenetic trees

Gene Ontology annotation reference GO_REF:0000044

Functional genomics reveals genes involved in protein secretion and Golgi organization.

PMID:34019822

Vmp1, Vps13D, and Marf/Mfn2 function in a conserved pathway to regulate mitochondria and ER contact in development and disease.

Drosophila Vmp1 is Tango5. Endogenous GFP-Vmp1 co-localizes with ER markers, and Vmp1 loss blocks Atg8a puncta formation and causes Ref2p accumulation.

"GFP-Vmp1 co-localizes with the ER markers Sec61β and SERCA in intestine cells"

PMID:33929485

TMEM41B and VMP1 are scramblases and regulate the distribution of cholesterol and phosphatidylserine.

PMID:33850023

A model for a partnership of lipid transfer proteins and scramblases in membrane expansion and organelle biogenesis.

file:genes/DROME/Tango5/Tango5-flybase.txt

Tango5-flybase.txt

file:DROME/Tango5/Tango5-uniprot.txt

Tango5-uniprot.txt

file:DROME/Tango5/Tango5-bioinformatics/RESULTS.md

Tango5 isoform and family placement (re-review 2026-10-21)

file:DROME/Tango5/Tango5-deep-research-falcon.md

DROME/Tango5/Tango5-deep-research-falcon.md