The research report should be a detailed narrative explaining the function, biological processes, and localization of the gene product. Citations should be given for all claims.
You should prioritize authoritative reviews and primary scientific literature when conducting research. You can supplement
this with annotations you find in gene/protein databases, but these can be outdated or inaccurate.
We are specifically interested in the primary function of the gene - for enzymes, what reaction is catalyzed, and what is the substrate specificity? For transporters, what is the substrate? For structural proteins or adapters, what is the broader structural role? For signaling molecules, what is the role in the pathway.
We are interested in where in or outside the cell the gene product carries out its function.
We are also interested in the signaling or biochemical pathways in which the gene functions. We are less interested in broad pleiotropic effects, except where these elucidate the precise role.
Include evidence where possible. We are interested in both experimental evidence as well as inference from structure, evolution, or bioinformatic analysis. Precise studies should be prioritized over high-throughput, where available.
FASCIATED EAR2 (FEA2) is a Zea mays CLAVATA2 (CLV2)-orthologous leucine-rich repeat receptor-like protein (LRR-RLP) that functions at the plasma membrane to restrict stem-cell proliferation in shoot and inflorescence meristems, thereby shaping ear/tassel architecture and yield-associated traits. Mechanistic evidence indicates that FEA2 acts as a shared signaling node for at least two CLE peptide inputs (ZmCLE7 and ZmFCP1), routing these signals into two separable downstream branches mediated by the heterotrimeric Gα CT2 (COMPACT PLANT2) and the membrane pseudokinase ZmCRN (CORYNE), respectively, with convergence on meristem homeostasis outputs including ZmWUS regulation. (je2018theclavatareceptor pages 1-2, je2018theclavatareceptor pages 12-14, je2018theclavatareceptor media 3b7154fc)
The literature evidence used here explicitly studies maize FASCIATED EAR2 (FEA2) as the maize ortholog of Arabidopsis CLAVATA2, described as an LRR receptor-like protein involved in CLE-mediated meristem signaling (consistent with UniProt Q940E8’s “CLAVATA2-like” description). (je2018theclavatareceptor pages 1-2)
Shoot and inflorescence meristems maintain a stem-cell reservoir while producing organ primordia; this balance is classically governed by a CLAVATA–WUSCHEL (CLV–WUS) negative feedback circuit where extracellular peptide signals restrict WUS-driven stem-cell maintenance. Reviews emphasize that meristem intercellular communication integrates mobile factors, hormones, small RNAs, and secreted peptides perceived by membrane-localized receptors, with CLV–WUS as a central organizing module. (demesaarevalo2024intercellularcommunicationin pages 1-3)
In maize, CLV-like receptors and CLE ligands (including ZmCLE7, a CLV3 homolog) are components of this conserved module; hormonal crosstalk (notably cytokinin) can modulate CLV-mediated feedback onto WUS output. (chaudhry2024hormonalinfluenceon pages 5-6)
FEA2 is repeatedly described as a CLV2-like receptor-like protein (LRR-RLP) rather than a receptor kinase, implying a primary role as a co-receptor/scaffold in receptor complexes rather than as an enzyme that catalyzes reactions. (je2018theclavatareceptor pages 1-2)
A key mechanistic concept in this system is that CLV2/FEA2 does not itself bind CLE peptides directly, and instead is proposed to act with other ligand-binding receptors (e.g., LRR receptor-like kinases) to transmit ligand-dependent signals. (je2018theclavatareceptor pages 1-2, je2018theclavatareceptor pages 12-14)
Je et al. (2018) provide direct evidence that FEA2 is required for signaling from at least two distinct CLE peptides:
- ZmCLE7 (maize CLV3 ortholog)
- ZmFCP1 (ZmFON2-LIKE CLE PROTEIN1)
In peptide-response assays, fea2 mutants show resistance to both peptide inputs, supporting the conclusion that FEA2 is required for both pathways. (je2018theclavatareceptor pages 9-12, je2018theclavatareceptor pages 3-6)
FEA2 forms complexes with two distinct downstream signaling partners:
- CT2 (COMPACT PLANT2), the α subunit of the maize heterotrimeric G protein
- ZmCRN, a CORYNE ortholog described as a membrane-localized pseudokinase
Biochemical evidence (co-immunoprecipitation) shows that CT2 can pull down FEA2, and ZmCRN can pull down FEA2; reciprocally, FEA2 can immunoprecipitate either CT2 or ZmCRN. (je2018theclavatareceptor pages 6-9, je2018theclavatareceptor pages 9-12)
BiFC detected a direct FEA2–ZmCRN interaction, while FEA2–CT2 interaction was not detected by BiFC in that assay context, consistent with the possibility that FEA2–CT2 association is indirect or occurs in a different complex organization. (je2018theclavatareceptor pages 6-9)
Evidence further indicates ZmCRN and CT2 are not recovered as a single three-way complex (i.e., ZmCRN did not immunoprecipitate CT2), supporting a model of distinct FEA2-containing complexes. (je2017theclavatareceptor pages 9-12, je2018theclavatareceptor pages 6-9)
A central mechanistic advance is that FEA2 transmits different CLE peptide inputs through different downstream effectors:
- ZmCLE7 → CT2 branch
- ZmFCP1 → ZmCRN branch
This is supported by differential peptide resistance in mutants: ct2 shows resistance primarily to ZmCLE7, while Zmcrn shows resistance primarily to ZmFCP1; fea2 is resistant to both, consistent with FEA2 being upstream of both branches. (je2018theclavatareceptor pages 12-14, je2018theclavatareceptor pages 9-12)
Genetic interactions further support parallel branches: Zmcrn;ct2 double mutants show additive/enhanced phenotypes, consistent with separable outputs, while fea2 is epistatic in the pathway placement. (je2018theclavatareceptor pages 12-14, je2018theclavatareceptor pages 6-9)
A schematic model from Je et al. summarizes these relationships (distinct FEA2 complexes feeding into CT2 vs ZmCRN and converging on nuclear outputs controlling meristem homeostasis). (je2018theclavatareceptor media 3b7154fc)
Je et al. experimentally confirmed plasma membrane localization of ZmCRN-mCherry and noted that this localization is consistent with FEA2 and CT2 localization, supporting a plasma-membrane signaling complex. (je2018theclavatareceptor pages 6-9)
Additionally, the authors infer that FEA2 is on the plasma membrane even in the absence of ZmCRN, because FEA2 still functions with CT2 in a crn mutant background. (je2018theclavatareceptor pages 12-14)
Together these data place the primary site of FEA2 action at the cell surface/plasma membrane, consistent with receptor complex-mediated perception/transduction of extracellular CLE signals. (je2018theclavatareceptor pages 6-9, je2018theclavatareceptor pages 12-14)
Within the retrieved primary-text passages, FEA2 is identified as an LRR receptor-like protein (CLV2-like), but a full enumeration of its LRR count, transmembrane segment boundaries, or cytosolic tail length is not explicitly provided in the quoted sections. (je2018theclavatareceptor pages 1-2, je2018theclavatareceptor pages 12-14)
By contrast, the related maize receptor-like protein FEA3 is explicitly described as having a signal peptide, multiple LRRs, a transmembrane domain, and a short cytosolic tail lacking a kinase domain—illustrating the typical architecture used by CLV-related RLPs in maize and supporting the general co-receptor model for FEA2. (je2016signalingfrommaize pages 1-5)
FEA2 restricts stem-cell proliferation in meristems; loss-of-function phenotypes in the pathway include enlarged shoot apical meristems and fasciated ears / enlarged ear inflorescence meristems, consistent with excess stem-cell accumulation. (je2018theclavatareceptor pages 6-9, je2018theclavatareceptor pages 9-12, wu2018roleofheterotrimeric pages 1-2)
Je et al. report quantitative increases in vegetative SAM size in downstream pathway mutants and enhanced phenotypes in double mutants, illustrating the magnitude of CLV-branch perturbations:
- Zmcrn vegetative SAM: 130.0 ± 4.1 µm vs 109.2 ± 4.6 µm in normal siblings (P < 0.0001)
- Other comparisons reported include larger SAMs in Zmcrn and fea2 single mutants (166.3 ± 8.3 µm and 176.1 ± 9.8 µm) vs normal (139.7 ± 4.8 µm), and Zmcrn;ct2 double mutant SAM size 191.8 ± 18.6 µm (P < 0.0001)
These measurements support the conclusion that the FEA2 network quantitatively constrains meristem size and that CT2 and ZmCRN act as separable downstream effectors. (je2018theclavatareceptor pages 3-6, je2018theclavatareceptor pages 2-3)
A 2024 Annual Review of Plant Biology review frames meristem regulation as an intercellular communication problem mediated by secreted peptides and membrane receptors; it highlights maize CLV pathway literature (including FEA2/CT2 and yield-relevant CLV studies) as part of the broader conceptual landscape of shoot meristem signaling and its crop-relevant implications. (demesaarevalo2024intercellularcommunicationin pages 1-3)
A 2024 review on hormonal influence in maize inflorescence development explicitly lists FEA2 as a maize CLV2 homolog within the CLV module and emphasizes that cytokinin can modulate CLV-mediated repression of WUS output, connecting the FEA2-containing module to hormonal regulation of meristem size and inflorescence patterning. (chaudhry2024hormonalinfluenceon pages 5-6)
Authoritative reviews and primary studies position CLV-WUS components as yield-trait levers (e.g., kernel row number), and explicitly discuss exploitation of weak alleles to tune meristem size without severe fasciation. (fletcher2018theclvwusstem pages 1-3, je2016signalingfrommaize pages 9-12)
A maize inflorescence-architecture review specifically reports “promising results using fea2 weak alleles in field trials”, citing Trung et al. 2020, and argues that these strategies may have potential to increase yield (qualitatively; quantitative outcomes not provided in the excerpt). (chen2021improvingarchitecturaltraits pages 5-6)
A key applied insight is that weak fea2 alleles can enhance kernel row number, but may not necessarily increase overall yield due to compensatory decreases in kernel size, highlighting the importance of optimizing allele strength and genetic background. (fletcher2018theclvwusstem pages 5-7, je2016signalingfrommaize pages 9-12)
Although not direct editing of FEA2 itself in the retrieved excerpts, an adjacent translational avenue is engineering the downstream CT2 (Gα) branch: constitutively active CT2 and CRISPR-based perturbations of non-canonical Gα-like proteins (XLGs) are reported to improve agronomic traits including kernel row number, spikelet density, and leaf angle, and the work explicitly discusses generating weak alleles (including via CRISPR) as a route to multi-trait improvement. (wu2018roleofheterotrimeric pages 1-2, wu2018roleofheterotrimeric pages 11-12)
Mechanistically, Je et al. (2018) provide an expert framework for how “promiscuous” receptor-like proteins can achieve ligand specificity: distinct ligands can be interpreted through distinct receptor complexes and downstream branches, using shared components such as FEA2 but different intracellular effectors (CT2 vs ZmCRN). (je2018theclavatareceptor pages 12-14, je2018theclavatareceptor media 3b7154fc)
From an applications perspective, reviews emphasize that meristem regulatory circuits (including CLV-WUS and maize CLV orthologs) are attractive targets because small, tunable shifts in meristem activity can translate into changes in organ number and yield components—but also stress the need to manage pleiotropy and trade-offs (e.g., kernel size). (fletcher2018theclvwusstem pages 1-3, fletcher2018theclvwusstem pages 5-7)
The following table consolidates key functional annotation points with evidence types and URLs/DOIs.
| Functional aspect | Key findings | Evidence type | Key sources with dates/URLs/DOIs |
|---|---|---|---|
| Identity / class | FEA2 in maize is the ortholog of Arabidopsis CLAVATA2 (CLV2) and is described as a leucine-rich repeat receptor-like protein (LRR-RLP) involved in CLAVATA/CLE meristem signaling. This matches the UniProt Q940E8 annotation for a CLAVATA2-like precursor protein in Zea mays. (je2018theclavatareceptor pages 1-2) | Primary genetics/mechanistic paper; review | Je et al., 2018, eLife, published Mar 2018, https://doi.org/10.7554/eLife.35673; Demesa-Arevalo et al., 2024, Annual Review of Plant Biology, first published Feb 29 2024, https://doi.org/10.1146/annurev-arplant-070523-035342 |
| Core molecular function | FEA2 functions as a shared/co-receptor-like signaling component in the maize CLV-WUS pathway, restricting stem-cell proliferation in shoot and inflorescence meristems. The evidence supports a signaling role rather than an enzymatic one; FEA2 helps transmit extracellular CLE-peptide information to intracellular downstream effectors that ultimately influence ZmWUS output. (je2018theclavatareceptor pages 1-2, je2018theclavatareceptor pages 12-14, je2018theclavatareceptor media 3b7154fc) | Genetic, biochemical, model synthesis, review | Je et al., 2018, eLife, Mar 2018, https://doi.org/10.7554/eLife.35673; Fletcher, 2018, Plants, Oct 19 2018, https://doi.org/10.3390/plants7040087 |
| Ligands / peptide inputs | The strongest direct evidence shows FEA2 mediates responses to at least two CLE-family peptides: ZmCLE7 (maize CLV3 ortholog) and ZmFCP1 (ZmFON2-LIKE CLE PROTEIN1). fea2 mutants are resistant to both peptide treatments, supporting the conclusion that FEA2 is required for signaling from both inputs. (je2018theclavatareceptor pages 1-2, je2018theclavatareceptor pages 9-12, je2018theclavatareceptor pages 3-6) | Peptide-response assays, genetics | Je et al., 2018, eLife, Mar 2018, https://doi.org/10.7554/eLife.35673 |
| Direct ligand binding vs co-receptor role | The study emphasizes that CLV2/FEA2 does not itself directly bind CLV3/CLE peptides, consistent with a co-receptor role. The proposed model is that FEA2 works with ligand-binding RLKs in different receptor complexes to relay distinct peptide signals. (je2018theclavatareceptor pages 1-2, je2018theclavatareceptor pages 12-14) | Mechanistic interpretation from primary paper | Je et al., 2018, eLife, Mar 2018, https://doi.org/10.7554/eLife.35673 |
| Receptor complexes / interaction partners | FEA2 associates with ZmCRN and CT2 in separate complexes. Co-immunoprecipitation showed ZmCRN pulls down FEA2, CT2 pulls down FEA2, and FEA2 can immunoprecipitate either partner; ZmCRN and CT2 do not appear to form one common three-way complex, implying distinct receptor assemblies. (je2018theclavatareceptor pages 6-9, je2017theclavatareceptor pages 9-12, je2018theclavatareceptor pages 9-12) | Biochemical interaction assays (Co-IP), BiFC, genetics | Je et al., 2018, eLife, Mar 2018, https://doi.org/10.7554/eLife.35673 |
| Downstream effectors / branch specificity | FEA2 routes different CLE signals through different downstream components: CT2 (heterotrimeric Gα, COMPACT PLANT2) primarily for ZmCLE7, and ZmCRN (CORYNE ortholog, pseudokinase) primarily for ZmFCP1. Additive phenotypes in Zmcrn;ct2 double mutants and differential peptide resistance support two parallel downstream branches under a common FEA2 node. (je2018theclavatareceptor pages 12-14, je2017theclavatareceptor pages 9-12, je2018theclavatareceptor pages 9-12, je2018theclavatareceptor media 3b7154fc) | Genetics, peptide assays, biochemical interaction, model | Je et al., 2018, eLife, Mar 2018, https://doi.org/10.7554/eLife.35673; Wu et al., 2018, PLOS Genetics, Apr 30 2018, https://doi.org/10.1371/journal.pgen.1007374 |
| Localization | Experimental evidence places the FEA2 signaling module at the plasma membrane. ZmCRN-mCherry was confirmed at the plasma membrane, co-localizing with FEA2/CT2-associated signaling; the authors further infer that FEA2 is on the plasma membrane even without ZmCRN because FEA2 still functions with CT2 in a crn background. (je2018theclavatareceptor pages 12-14, je2018theclavatareceptor pages 6-9, je2018theclavatareceptor pages 14-15) | Imaging, membrane-associated biochemical assays, inference from genetics | Je et al., 2018, eLife, Mar 2018, https://doi.org/10.7554/eLife.35673 |
| Domain / structure inference | In the retrieved evidence, FEA2 is consistently described as an LRR receptor-like protein rather than a kinase, fitting a model of extracellular ligand perception with limited intracellular signaling capacity. The primary paper provides more explicit structural detail for partner ZmCRN (a transmembrane pseudokinase) than for FEA2, reinforcing the idea that FEA2 likely signals through associated proteins rather than intrinsic kinase activity. (je2018theclavatareceptor pages 1-2, je2018theclavatareceptor pages 14-15) | Annotation plus mechanistic inference | Je et al., 2018, eLife, Mar 2018, https://doi.org/10.7554/eLife.35673 |
| Pathway position | FEA2 acts in the conserved CLAVATA-WUSCHEL feedback system that balances stem-cell maintenance and organ initiation. Recent reviews place maize FEA2 alongside TD1/CLV1, FEA3, ZmCLE7, and cytokinin-responsive control of ZmWUS1, showing FEA2 is part of a broader meristem signaling network rather than an isolated receptor. (chaudhry2024hormonalinfluenceon pages 5-6, demesaarevalo2024intercellularcommunicationin pages 1-3) | Review synthesis anchored in primary studies | Demesa-Arevalo et al., 2024, Annual Review of Plant Biology, Feb 29 2024, https://doi.org/10.1146/annurev-arplant-070523-035342; Chaudhry et al., 2024, Plant Reproduction, Oct 2024, https://doi.org/10.1007/s00497-024-00510-0 |
| Developmental roles / mutant phenotypes | Loss of FEA2 causes enlarged shoot apical and ear inflorescence meristems and fasciated ears, consistent with excess stem-cell proliferation. Reviews and primary studies also connect FEA2/CLV signaling to inflorescence architecture traits such as spikelet organization and kernel row number. (je2018theclavatareceptor pages 6-9, je2018theclavatareceptor pages 9-12, wu2018roleofheterotrimeric pages 1-2) | Mutant phenotyping, review | Je et al., 2018, eLife, Mar 2018, https://doi.org/10.7554/eLife.35673; Wu et al., 2018, PLOS Genetics, Apr 30 2018, https://doi.org/10.1371/journal.pgen.1007374 |
| Quantitative data | In the FEA2 signaling network, Zmcrn mutants had larger vegetative SAMs than normal siblings (130.0 ± 4.1 µm vs 109.2 ± 4.6 µm; P < 0.0001), and additional comparisons showed larger SAMs in Zmcrn and fea2 single mutants (166.3 ± 8.3 µm and 176.1 ± 9.8 µm) versus normal (139.7 ± 4.8 µm); the Zmcrn;ct2 double mutant reached 191.8 ± 18.6 µm. These data support FEA2-linked control of meristem size and parallel downstream pathways. (je2018theclavatareceptor pages 3-6, je2018theclavatareceptor pages 2-3) | Quantitative genetics / morphometrics | Je et al., 2018, eLife, Mar 2018, https://doi.org/10.7554/eLife.35673 |
| Natural variation / agronomic trait association | Independent work cited in the retrieved evidence identifies FEA2 as a locus controlling quantitative variation in maize kernel row number (KRN), making it one of the clearest CLV-pathway examples with agronomic relevance in maize. Related signaling components such as ZmCRN also show KRN-associated polymorphisms in the retrieved evidence. (liu2025multiomicsanalysisof pages 12-12, je2018theclavatareceptor pages 3-6) | QTL/association context, review citation of primary study | Bommert et al., 2013, Nature Genetics, Feb 2013, https://doi.org/10.1038/ng.2534; Je et al., 2018, eLife, Mar 2018, https://doi.org/10.7554/eLife.35673 |
| Applications / real-world implementation | Reviews and follow-up studies present FEA2 as a crop-improvement target for tuning meristem size and yield-related traits. Chen & Gallavotti (2021) specifically note promising field-trial results with fea2 weak alleles, while broader maize G-protein engineering studies show that modulating the linked CT2 branch can improve spikelet density, kernel row number, and leaf angle—supporting practical meristem engineering strategies built around the FEA2 network. (chen2021improvingarchitecturaltraits pages 5-6, wu2018roleofheterotrimeric pages 1-2, wu2018roleofheterotrimeric pages 11-12) | Review, field-translation context, transgenic trait engineering | Chen & Gallavotti, 2021, Molecular Breeding, Feb 2021, https://doi.org/10.1007/s11032-021-01212-5; Wu et al., 2018, PLOS Genetics, Apr 30 2018, https://doi.org/10.1371/journal.pgen.1007374 |
Table: This table summarizes the strongest evidence-supported functional annotation points for maize FEA2, including mechanism, partners, localization, phenotypes, and agronomic relevance. It is designed as a compact reference for building a full research report on UniProt Q940E8.
A schematic model figure from Je et al. summarizes FEA2-dependent bifurcation of CLE signaling through CT2 versus ZmCRN and convergence on meristem homeostasis outputs. (je2018theclavatareceptor media 3b7154fc)
1) The seminal maize QTL paper identifying FEA2 as controlling kernel row number (Bommert et al., Nature Genetics 2013; https://doi.org/10.1038/ng.2534) is cited by reviews in the retrieved corpus but was flagged as unobtainable for full-text extraction in this run; thus, numeric effect sizes for the FEA2 KRN QTL are not reproduced here from the primary source. (demesaarevalo2024intercellularcommunicationin pages 20-21)
2) Detailed domain architecture (e.g., exact number/positions of LRRs and transmembrane boundaries) for FEA2 is not explicitly quoted in the retrieved text segments; the report therefore limits domain claims to what is directly supported (LRR receptor-like protein / CLV2 ortholog) and flags that deeper structural annotation would require direct database/sequence analysis beyond the passages retrieved here. (je2018theclavatareceptor pages 1-2, je2018theclavatareceptor pages 12-14)
References
(je2018theclavatareceptor pages 1-2): Byoung Il Je, Fang Xu, Qingyu Wu, Lei Liu, Robert Meeley, Joseph P Gallagher, Leo Corcilius, Richard J Payne, Madelaine E Bartlett, and David Jackson. The clavata receptor fasciated ear2 responds to distinct cle peptides by signaling through two downstream effectors. eLife, Mar 2018. URL: https://doi.org/10.7554/elife.35673, doi:10.7554/elife.35673. This article has 136 citations and is from a domain leading peer-reviewed journal.
(je2018theclavatareceptor pages 12-14): Byoung Il Je, Fang Xu, Qingyu Wu, Lei Liu, Robert Meeley, Joseph P Gallagher, Leo Corcilius, Richard J Payne, Madelaine E Bartlett, and David Jackson. The clavata receptor fasciated ear2 responds to distinct cle peptides by signaling through two downstream effectors. eLife, Mar 2018. URL: https://doi.org/10.7554/elife.35673, doi:10.7554/elife.35673. This article has 136 citations and is from a domain leading peer-reviewed journal.
(je2018theclavatareceptor media 3b7154fc): Byoung Il Je, Fang Xu, Qingyu Wu, Lei Liu, Robert Meeley, Joseph P Gallagher, Leo Corcilius, Richard J Payne, Madelaine E Bartlett, and David Jackson. The clavata receptor fasciated ear2 responds to distinct cle peptides by signaling through two downstream effectors. eLife, Mar 2018. URL: https://doi.org/10.7554/elife.35673, doi:10.7554/elife.35673. This article has 136 citations and is from a domain leading peer-reviewed journal.
(demesaarevalo2024intercellularcommunicationin pages 1-3): Edgar Demesa-Arevalo, Madhumitha Narasimhan, and Rüdiger Simon. Intercellular communication in shoot meristems. Jul 2024. URL: https://doi.org/10.1146/annurev-arplant-070523-035342, doi:10.1146/annurev-arplant-070523-035342. This article has 20 citations and is from a domain leading peer-reviewed journal.
(chaudhry2024hormonalinfluenceon pages 5-6): Amina Chaudhry, Zongliang Chen, and Andrea Gallavotti. Hormonal influence on maize inflorescence development and reproduction. Plant Reproduction, 37:393-407, Oct 2024. URL: https://doi.org/10.1007/s00497-024-00510-0, doi:10.1007/s00497-024-00510-0. This article has 15 citations.
(je2018theclavatareceptor pages 9-12): Byoung Il Je, Fang Xu, Qingyu Wu, Lei Liu, Robert Meeley, Joseph P Gallagher, Leo Corcilius, Richard J Payne, Madelaine E Bartlett, and David Jackson. The clavata receptor fasciated ear2 responds to distinct cle peptides by signaling through two downstream effectors. eLife, Mar 2018. URL: https://doi.org/10.7554/elife.35673, doi:10.7554/elife.35673. This article has 136 citations and is from a domain leading peer-reviewed journal.
(je2018theclavatareceptor pages 3-6): Byoung Il Je, Fang Xu, Qingyu Wu, Lei Liu, Robert Meeley, Joseph P Gallagher, Leo Corcilius, Richard J Payne, Madelaine E Bartlett, and David Jackson. The clavata receptor fasciated ear2 responds to distinct cle peptides by signaling through two downstream effectors. eLife, Mar 2018. URL: https://doi.org/10.7554/elife.35673, doi:10.7554/elife.35673. This article has 136 citations and is from a domain leading peer-reviewed journal.
(je2018theclavatareceptor pages 6-9): Byoung Il Je, Fang Xu, Qingyu Wu, Lei Liu, Robert Meeley, Joseph P Gallagher, Leo Corcilius, Richard J Payne, Madelaine E Bartlett, and David Jackson. The clavata receptor fasciated ear2 responds to distinct cle peptides by signaling through two downstream effectors. eLife, Mar 2018. URL: https://doi.org/10.7554/elife.35673, doi:10.7554/elife.35673. This article has 136 citations and is from a domain leading peer-reviewed journal.
(je2017theclavatareceptor pages 9-12): Byoung Il Je, Fang Xu, Qingyu Wu, Lei Liu, Robert Meeley, and David Jackson. The clavata receptor fasciated ear2 responds to different cle peptides by signaling through different downstream effectors. bioRxiv, Oct 2017. URL: https://doi.org/10.1101/194951, doi:10.1101/194951. This article has 0 citations.
(je2016signalingfrommaize pages 1-5): Byoung Il Je, Jeremy Gruel, Young Koung Lee, Peter Bommert, Edgar Demesa Arevalo, Andrea L Eveland, Qingyu Wu, Alexander Goldshmidt, Robert Meeley, Madelaine Bartlett, Mai Komatsu, Hajime Sakai, Henrik Jönsson, and David Jackson. Signaling from maize organ primordia via fasciated ear3 regulates stem cell proliferation and yield traits. Nature Genetics, 48:785-791, May 2016. URL: https://doi.org/10.1038/ng.3567, doi:10.1038/ng.3567. This article has 296 citations and is from a highest quality peer-reviewed journal.
(wu2018roleofheterotrimeric pages 1-2): Qingyu Wu, Michael Regan, Hiro Furukawa, and David Jackson. Role of heterotrimeric gα proteins in maize development and enhancement of agronomic traits. PLOS Genetics, 14:e1007374, Apr 2018. URL: https://doi.org/10.1371/journal.pgen.1007374, doi:10.1371/journal.pgen.1007374. This article has 89 citations and is from a domain leading peer-reviewed journal.
(je2018theclavatareceptor pages 2-3): Byoung Il Je, Fang Xu, Qingyu Wu, Lei Liu, Robert Meeley, Joseph P Gallagher, Leo Corcilius, Richard J Payne, Madelaine E Bartlett, and David Jackson. The clavata receptor fasciated ear2 responds to distinct cle peptides by signaling through two downstream effectors. eLife, Mar 2018. URL: https://doi.org/10.7554/elife.35673, doi:10.7554/elife.35673. This article has 136 citations and is from a domain leading peer-reviewed journal.
(fletcher2018theclvwusstem pages 1-3): Jennifer C. Fletcher. The clv-wus stem cell signaling pathway: a roadmap to crop yield optimization. Plants, 7:87, Oct 2018. URL: https://doi.org/10.3390/plants7040087, doi:10.3390/plants7040087. This article has 128 citations.
(je2016signalingfrommaize pages 9-12): Byoung Il Je, Jeremy Gruel, Young Koung Lee, Peter Bommert, Edgar Demesa Arevalo, Andrea L Eveland, Qingyu Wu, Alexander Goldshmidt, Robert Meeley, Madelaine Bartlett, Mai Komatsu, Hajime Sakai, Henrik Jönsson, and David Jackson. Signaling from maize organ primordia via fasciated ear3 regulates stem cell proliferation and yield traits. Nature Genetics, 48:785-791, May 2016. URL: https://doi.org/10.1038/ng.3567, doi:10.1038/ng.3567. This article has 296 citations and is from a highest quality peer-reviewed journal.
(chen2021improvingarchitecturaltraits pages 5-6): Zongliang Chen and Andrea Gallavotti. Improving architectural traits of maize inflorescences. Molecular Breeding : New Strategies in Plant Improvement, Feb 2021. URL: https://doi.org/10.1007/s11032-021-01212-5, doi:10.1007/s11032-021-01212-5. This article has 34 citations.
(fletcher2018theclvwusstem pages 5-7): Jennifer C. Fletcher. The clv-wus stem cell signaling pathway: a roadmap to crop yield optimization. Plants, 7:87, Oct 2018. URL: https://doi.org/10.3390/plants7040087, doi:10.3390/plants7040087. This article has 128 citations.
(wu2018roleofheterotrimeric pages 11-12): Qingyu Wu, Michael Regan, Hiro Furukawa, and David Jackson. Role of heterotrimeric gα proteins in maize development and enhancement of agronomic traits. PLOS Genetics, 14:e1007374, Apr 2018. URL: https://doi.org/10.1371/journal.pgen.1007374, doi:10.1371/journal.pgen.1007374. This article has 89 citations and is from a domain leading peer-reviewed journal.
(je2018theclavatareceptor pages 14-15): Byoung Il Je, Fang Xu, Qingyu Wu, Lei Liu, Robert Meeley, Joseph P Gallagher, Leo Corcilius, Richard J Payne, Madelaine E Bartlett, and David Jackson. The clavata receptor fasciated ear2 responds to distinct cle peptides by signaling through two downstream effectors. eLife, Mar 2018. URL: https://doi.org/10.7554/elife.35673, doi:10.7554/elife.35673. This article has 136 citations and is from a domain leading peer-reviewed journal.
(liu2025multiomicsanalysisof pages 12-12): Jing Liu, Tianxiao Yang, Zhuoya Gao, Jianxin Li, Tuan Li, Jialei Ou, Yalan Li, Shuaishuai Zhang, Yinuo Wang, Hui-ling Xie, Weihua Li, Jihua Tang, and Pengshuai Yan. Multi-omics analysis of the maize ear diameter mutant3 (zmed3) provides insights into female inflorescence development. BMC Plant Biology, Oct 2025. URL: https://doi.org/10.1186/s12870-025-07439-0, doi:10.1186/s12870-025-07439-0. This article has 0 citations and is from a peer-reviewed journal.
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