Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
WFS1 (Wolfram syndrome 1) gene product: predominant subcellular localization to endoplasmic reticulum in cultured cells and neuronal expression in rat brain.
Wolframin expression induces novel ion channel activity in endoplasmic reticulum membranes and increases intracellular calcium.
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WFS1 is localized to the ER in brain hippocampus and pancreatic beta-cells
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Reconstitution demonstrated cation-selective ion channel activity
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WFS1 expression increases cytosolic calcium levels
Endoplasmic reticulum stress induces Wfs1 gene expression in pancreatic beta-cells via transcriptional activation.
Expressional and functional studies of Wolframin, the gene function deficient in Wolfram syndrome, in mice and patient cells.
WFS1 protein modulates the free Ca(2+) concentration in the endoplasmic reticulum.
Mutations in the WFS1 gene are a frequent cause of autosomal dominant nonsyndromic low-frequency hearing loss in Japanese.
Sodium-potassium ATPase 1 subunit is a molecular partner of Wolframin, an endoplasmic reticulum protein involved in ER stress.
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WFS1 interacts with Na+/K+ ATPase beta1 subunit
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Interaction important for ATPase maturation
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WFS1 deficiency reduces ATPase expression
Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells.
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WFS1 negatively regulates ATF6alpha through ubiquitin-proteasome pathway
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WFS1 stabilizes HRD1 E3 ubiquitin ligase
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WFS1 enhances ATF6alpha ubiquitination and proteasomal degradation
Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells.
Vacuolar-type H+-ATPase V1A subunit is a molecular partner of Wolfram syndrome 1 (WFS1) protein, which regulates its expression and stability.
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WFS1 interacts with V-ATPase V1A subunit
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WFS1 stabilizes V1A subunit through proteasome-independent mechanism
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WFS1 also localizes to secretory granules
Endoplasmic reticulum stress and Parkinson's disease: the role of HRD1 in averting apoptosis in neurodegenerative disease.
Sarco(endo)plasmic reticulum ATPase is a molecular partner of Wolfram syndrome 1 protein, which negatively regulates its expression.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram Syndrome).
Diabetes insipidus, diabetes mellitus, optic atrophy and deafness (DIDMOAD) caused by mutations in a novel gene (wolframin) coding for a predicted transmembrane protein.
FAM20C phosphorylates FAM20C substrates
Deep research report on WFS1