ced-1 notes

Provider deep research was not run: Falcon returned 402 and the OpenAI key was invalid in this environment (see genes/human/MEGF10/MEGF10-notes.md). This synthesis was made by hand from cached publications.

Core

• Receptor: PMID:11163239. It acts in engulfing cells: PMID:11163239.
• Ligand bridge: PMID:20526330. The binding site is the EMI domain: PMID:22713871.
• Adaptor: PMID:11729193.
• Phagosome maturation: PMID:18351800.
• Recycling: PMID:35929733.

Killing role (worm-specific, regulatory)

• PMID:11449278
• PMID:11449279
• CED-1 therefore promotes death, which fits positive regulation of apoptotic process. It does not take part in the dying cell's own program.

Background-genotype annotations (see projects/APOPTOSIS/ASSAY_READOUT_OVERANNOTATION.md)

• PMID:24225442 (CED-8) and PMID:23505386 (CSP-1) use ced-1(e1735) only as a background that makes corpses persist so they can be counted: PMID:24225442. Also PMID:23505386. The ced-1 apoptosis annotations taken from these papers attribute the background genotype's role to the gene being studied.

Wnt paper (PMID:20126385)

• DTC migration: PMID:20126385.
• Spindle: PMID:20126385.

Round 6 of projects/INVOLVED_IN_PRECOMPOSITION.md (2026-11-10): the two GO:1902742 MODIFY replacements and the four GOA GO:1904747 rows (previously KEEP_AS_NON_CORE, now MODIFY) now use GO:0043065 positive regulation of apoptotic process instead of the precomposed GO:1904747 positive regulation of apoptotic process involved in development, with decomposed_into.context_dropped. The sign correction (the gene promotes death from the engulfing cell rather than taking part in the dying cell's program) is unchanged; only the developmental context is dropped. Earlier mentions of GO:1904747 above are superseded.