Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on UniPathway vocabulary mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
UniProt entry A0A1J6KZ94 for Nicotiana attenuata FOX1_4
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FOX1_4 is a BBL-family nicotine-associated oxidoreductase
"Involved in the biosynthesis of pyridine alkaloid natural products, leading mainly to the production of anabasine, anatabine, nicotine and nornicotine ... Catalyzes a late oxidation step subsequent to the pyridine ring condensation reaction in the biosynthesis of alkaloids."
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UniProt places FOX1_4 in vacuole
"CC -!- SUBCELLULAR LOCATION: Vacuole {ECO:0000256|ARBA:ARBA00004116}."
NaBBL FOX1_4 candidate notes
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The BBL family now has strong late-pathway support
"The full preprint identifies BBLa/NicGS as the BBL-family enzyme responsible for stereoselective late-pathway oxidation in nicotine synthesis, so FOX1_4 remains a substantive BBL-like candidate rather than a generic flavoprotein bystander."
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FOX1_4 is still an unresolved paralog rather than a settled primary copy
"The paper sharpens the biological role of the family but does not settle which current NICAT BBL paralog corresponds to the tobacco NicGS enzyme."