GJC2 review notes

2026-11-05 — private whole proposal

Fourteen current contexts are preserved individually: thirteen ACCEPT and one TOO_GENERAL. The three ancestral assertions were checked against the actual family tree and IBD records. One channel core summarizes the accepted biology; no NEW annotation or canonical-only product slot is proposed.

The manual evidence centralizes construct, organism and assay limits. The current 439-residue sequence remains distinct from historical experimental constructs. Source availability records distinguish selected external originals from eventual normal-cache contents.

This is a private proposal. No native target fetch, seed, CREATE history, validation or render has occurred for GJC2. The source plan has twelve paths: seven exact main reuses and five prospective missing publications. Actual native reconciliation and checks remain required before publication.

2026-11-05 — native execution and affected checks

The genuine seed, all fourteen machine dictionaries and all sixteen export columns match the proposal. Seven source files were reused unchanged and five missing publications acquired. Native PMID:15192806 now has fuller original text, without changing the approved scientific assessment. Cache flags and three whitespace-only excerpts were reconciled.

Default validation and strict original-context matching passed. Two advisories remain: the PANTHER reference resolver cannot fetch the family identifier, and the manual-page citation rule does not count additional-reference links. Independently retained family evidence and original-source support remain intact. Computed DRAFT was applied and confirmed; the genuine CREATE history validated and private rendering passed. No scientific decision changed for validation. Publication has not occurred.

2026-11-05 — direct manual support and final local status

An exact four-word manual-page anchor was added to the existing core support. The first attempt used an unsupported database-section field on a manual source; that diagnostic was preserved and the field omitted. Default validation now passes with only the PANTHER reference resolver limitation. The actual helper computes COMPLETE, and that scalar was applied and confirmed. Strict original matching remains unchanged; final history validation and private rendering passed. The initial DRAFT reports above remain historical diagnostics. No external source, action, core term or product changed. Publication remains pending.

2026-11-06 — localization and channel interpretation

Human Cx47 supports channel coupling; the tissue-localization experiment used rhesus oligodendrocytes PMID:17344063(https://pmc.ncbi.nlm.nih.gov/articles/PMC1937038/). Mouse myelin staining supports the transferred annotation, while human sheath localization remains unresolved PMID:20578039(https://doi.org/10.1002/glia.21032). The core now records plasma membrane and gap junction.

The deposited-sequence comparison separates accession sequences from unsequenced experimental plasmids. Opposing-cell connexin pairing is distinct from subunit mixing within a connexon.