Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Annexin I is stored within gelatinase granules of human neutrophil and mobilized on the cell surface upon adhesion but not phagocytosis.
A novel ligand of the formyl peptide receptor: annexin I regulates neutrophil extravasation by interacting with the FPR.
Small proline-rich protein 1 is the major component of the cell envelope of normal human oral keratinocytes.
Solution structure and membrane-binding property of the N-terminal tail domain of human annexin I.
An annexin 1 N-terminal peptide activates leukocytes by triggering different members of the formyl peptide receptor family.
Identification and characterization of the acidic pH binding sites for growth regulatory ligands of low density lipoprotein receptor-related protein-1.
Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis.
Annexin-1 modulates T-cell activation and differentiation.
Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense.
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Annexin A1 regulates hormone exocytosis through a mechanism involving actin reorganization.
Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6.
Protein profile of exosomes from trabecular meshwork cells.
Characterization of Ca2(+)-dependent phospholipid binding, vesicle aggregation and membrane fusion by annexins.
Annexin-1 interacts with NEMO and RIP1 to constitutively activate IKK complex and NF-κB: implication in breast cancer metastasis.
Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation.
Annexin A1 regulates neutrophil clearance by macrophages in the mouse bone marrow.
Suppression of MIP-2 or IL-8 production by annexins A1 and A4 during coculturing of macrophages with late apoptotic human peripheral blood neutrophils.
Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach.
Annexin-1-mediated endothelial cell migration and angiogenesis are regulated by vascular endothelial growth factor (VEGF)-induced inhibition of miR-196a expression.
Cathepsin G-regulated release of formyl peptide receptor agonists modulate neutrophil effector functions.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy.
Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms.
Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.
A dimeric form of lipocortin-1 in human placenta.
E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair.
Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.
Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.
Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity.
Cloning and expression of cDNA for human endonexin II, a Ca2+ and phospholipid binding protein.
Two human 35 kd inhibitors of phospholipase A2 are related to substrates of pp60v-src and of the epidermal growth factor receptor/kinase.
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Global mapping of Salmonella enterica-host protein-protein interactions during infection.
Calcium-dependent binding of S100C to the N-terminal domain of annexin I.
Folding properties of an annexin I domain: a 1H-15N NMR and CD study.
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
Liganded Gi-activating GPCR acts as a GEF for Gi
FPRL2 receptor binds a wide range of ligands
Expression of IL4, IL13-upregulated extracellular proteins
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
The Ligand:GPCR:Gq complex dissociates
The Ligand:GPCR:Gi complex dissociates
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
UniProt entry P04083 (ANXA1_HUMAN)
Annexin A1 and glucocorticoids as effectors of the resolution of inflammation.
Aberrant inflammation and resistance to glucocorticoids in annexin 1-/- mouse.
A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion.
Structural basis of the Ca(2+)-dependent association between S100C (S100A11) and its target, the N-terminal part of annexin I.
Structural characterization of a biologically active human lipocortin 1 expressed in Escherichia coli.
Inhibition of human cytosolic phospholipase A2 by human annexin V.
Annexin A1 Tethers Membrane Contact Sites that Mediate ER to Endosome Cholesterol Transport.
Falcon deep research report for human ANXA1
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ANXA1 is a calcium-regulated membrane-binding scaffold and extracellular pro-resolution signal acting principally through FPR2/ALX, not a metabolic enzyme.
"**ANXA1 is a calcium-regulated membrane-binding scaffold and an extracellular pro-resolution signal—not a metabolic enzyme or transporter.**"
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Endosomal ANXA1 with ER-associated S100A11 tethers ER-MVB membrane contact sites (Eden et al. 2016).
"There, endosomal ANXA1 and ER-associated **S100A11** help tether the two membranes."