GO_REF:0000002

Gene Ontology annotation through association of InterPro records with GO terms

GO_REF:0000043

Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

file:ANOGA/TEP2/TEP2-deep-research-falcon.md

Deep research report on TEP2 in Anopheles gambiae

TEP2 is a thioester-containing protein in a gene cluster on chromosome 3R

"TEP2 is a distinct An. gambiae TEP gene in a multi-gene cluster on chromosome arm 3R (29A-30E). TEP2 lies very close to TEP15"
TEP2 has an intact thioester motif consistent with opsonin function

"TEP2 is annotated with a present thioester (TE) motif, consistent with complement-like opsonin function"
TEP2 is induced in immune-perturbed mosquitoes

"In A. gambiae mosGILT-null, TEP2 (AGAP008366) whole-body transcript levels increased ~9-fold versus wild type (p=0.0001)"

file:ANOGA/TEP2/TEP2-uniprot.txt

UniProt entry for TEP2 (Q5TQC0)

TEP2 is predicted to be secreted

"SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}"

DOI:10.1126/science.1077136

Immunity-Related Genes and Gene Families in <i>Anopheles gambiae</i>

TEP2 is located in a TEP gene cluster on chromosome 3R

"TEP2 is a distinct An. gambiae TEP gene in a multi-gene cluster on chromosome arm 3R (29A-30E)"
TEP2 has an intact thioester motif

"TEP2 is annotated with a present thioester (TE) motif, consistent with complement-like opsonin function"

DOI:10.3389/fimmu.2017.00759

Evolution and Function of Thioester-Containing Proteins and the Complement System in the Innate Immune Response

TEPs function as innate immune effectors via thioester-mediated pathogen binding

"Thioester-containing proteins (TEPs): Secreted innate immune effectors with a reactive thioester (GCGEQ) that can form covalent bonds with microbial surfaces"
Insect TEPs are functionally analogous to vertebrate complement

"In insects, TEPs are functionally analogous to vertebrate complement factors (e.g., C3), contributing to recognition, opsonization, and clearance by phagocytosis and/or lysis"

DOI:10.1073/pnas.1010575107

A heterodimeric complex of the LRR proteins LRIM1 and APL1C regulates complement-like immunity in <i>Anopheles gambiae</i>

TEP1 circulates in hemolymph in complex with LRIM1/APL1C

"In the canonical mosquito complement-like pathway, TEP1 is stabilized and delivered by LRIM1/APL1C until deposition on pathogens"

DOI:10.1186/s12864-023-09887-0

mosGILT controls innate immunity and germ cell development in Anopheles gambiae

TEP2 is strongly induced in immune-perturbed mosquitoes

"In A. gambiae mosGILT-null, TEP2 (AGAP008366) whole-body transcript levels increased ~9-fold versus wild type (p=0.0001)"