Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

GO_REF:0000108

Automatic assignment of GO terms using logical inference, based on on inter-ontology links

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:11104662

CHRNB2 is the second acetylcholine receptor subunit associated with autosomal dominant nocturnal frontal lobe epilepsy.

The inspected experiments establish beta2 epilepsy-related channel effects rather than a beta1-specific nervous-system experiment.

PMID:15701510

Refined structure of the nicotinic acetylcholine receptor at 4A resolution.

The native Torpedo receptor structure defines the heteropentamer and pore architecture that contextualize the muscle receptor family.

PMID:16874522

Gene-based analysis suggests association of the nicotinic acetylcholine receptor beta1 subunit (CHRNB1) and M1 muscarinic acetylcholine receptor (CHRM1) with vulnerability for nicotine dependence.

CHRNB1 variation is associated with nicotine-dependence measures in the tested families; causal beta1 molecular participation remains unresolved.

PMID:21480901

Multiple inhibitory actions of lidocaine on Torpedo nicotinic acetylcholine receptors transplanted to Xenopus oocytes.

Acetylcholine-elicited currents through transplanted Torpedo receptors are inhibited by lidocaine through several receptor-level mechanisms.

PMID:32296183

A reference map of the human binary protein interactome.

HuRI identifies an assay-supported CHRNB1–ASB6 interaction without establishing receptor ubiquitination or native encounter.

PMID:7531341

Congenital myasthenic syndrome caused by prolonged acetylcholine receptor channel openings due to a mutation in the M2 domain of the epsilon subunit.

Wild-type beta1 participates in assembled muscle receptors; epsilon mutation causes prolonged channel openings in the investigated human disease and mouse reconstitution systems.

PMID:8651643

A beta-subunit mutation in the acetylcholine receptor channel gate causes severe slow-channel syndrome.

A beta gate mutation prolongs openings and is associated with severe endplate myopathy and postsynaptic remodeling.

PMID:8872460

New mutations in acetylcholine receptor subunit genes reveal heterogeneity in the slow-channel congenital myasthenic syndrome.

Beta1 mutation alters assembled receptor gating, with human endplate pathology and mouse receptor reconstitution providing distinct evidence.

PMID:27375219

Mutations Causing Slow-Channel Myasthenia Reveal That a Valine Ring in the Channel Pore of Muscle AChR is Optimized for Stabilizing Channel Gating.

Human beta1 pore mutation changes opening/closing kinetics, demonstrating its functional contribution to channel gating.

PMID:16527851

The human adult subtype ACh receptor channel has high Ca2+ permeability and predisposes to endplate Ca2+ overloading.

Beta1-containing human muscle receptors conduct calcium as a fraction of their cation current.

PMID:40203823

Autoimmune mechanisms elucidated through muscle acetylcholine receptor structures.

Human receptor structures locate beta1 in the pore and gating machinery while canonical ACh sites lie at alpha1–delta/epsilon interfaces.

PMID:24194945

Energetic contributions to channel gating of residues in the muscle nicotinic receptor β1 subunit.

Beta1 contributes to allosteric gating, while receptor-affinity measurements and canonical transmitter contacts are distinct properties.

file:human/CHRNB1/CHRNB1-source-evidence.json

CHRNB1 source-specific channel, ligand, product and propagation evidence