NRROS (LRRC33) curation notes

Deep research (falcon/perplexity-lite) unavailable; notes from UniProt Q86YC3 and cached papers.

• Topology: signal 1-18, extracellular LRR region 19-650, TM 651-671, cytoplasmic 672-692 (type I).
• Milieu molecule for proTGF-beta1 PMID:29909984.
• Surface pool is the 120 kDa glycoform only; much of LRRC33 intracellular (PMID:29909984).
• ER colocalization with calnexin (PMID:32197075); disease variants impair active TGF-beta1 delivery.
• ROS hypothesis refuted: PMID:29909984; Cybb loss does not rescue.
• TLR inhibition (PMID:23545260) probably secondary to TGF-beta (UniProt).

Localization conclusion: dual - plasma membrane/cell surface (functional mature glycoform, type I, LRR
ectodomain extracellular) plus a large ER-membrane pool. Surface level is low/regulated (PMA increases).