Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Combined Automated Annotation using Multiple IEA Methods
Decyanation of vitamin B12 by a trafficking chaperone.
Mechanism of vitamin B12-responsiveness in cblC methylmalonic aciduria with homocystinuria.
A human vitamin B12 trafficking protein uses glutathione transferase activity for processing alkylcobalamins.
Structural basis of multifunctionality in a vitamin B12-processing enzyme.
Structure of MMACHC reveals an arginine-rich pocket and a domain-swapped dimer for its B12 processing function.
Subcellular location of MMACHC and MMADHC, two human proteins central to intracellular vitamin B(12) metabolism.
The C-terminal domain of CblD interacts with CblC and influences intracellular cobalamin partitioning.
Interaction between methionine synthase isoforms and MMACHC: characterization in cblG-variant, cblG and cblC inherited causes of megaloblastic anaemia.
Purification and interaction analyses of two human lysosomal vitamin B12 transporters: LMBD1 and ABCD4.
Pathogenic mutations differentially affect the catalytic activities of the human B12-processing chaperone CblC and increase futile redox cycling.
Methionine synthase and methionine synthase reductase interact with MMACHC and with MMADHC.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
MMACHC:cob(II)alamin binds MMADHC
MMADHC targets transport of cytosolic cob(II)alamin to mitochondria
cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR
Defective MMADHC does not bind MMACHC:B12r
Defective MMACHC does not reduce Cbl
Defective MMACHC does not decyanate CNCbl
Cobalamin (Cbl) metabolism
Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin