rde-3 / mut-2 (O44768) review notes

Provenance / process

• Fetched with just fetch-gene worm O44768 --alias rde-3. This is TrEMBL O44768, 441 aa, WormBase K04F10.6, the same accession as the module. Note that Preston et al. found UG-addition activity only for isoform MUT-2a PMID:30988468.
• Deep research FAILED (falcon timeout; perplexity fallback not configured). No deep-research file was written.

Key findings

• Poly(UG) polymerase: PMID:30988468.
• In vivo: PMID:32499657 and PMID:32499657.
• Genetics: PMID:15723801.
• Antiviral: RDE-3 pUGylates Orsay virus RNAs PMID:41165327.

Curation decisions

• No GO term exists for poly(UG) polymerase activity. A new term was proposed (parent GO:0098680), and the core function uses proposed_molecular_function. The IBA for RNA uridylyltransferase activity was accepted as correct but incomplete.
• The IBA for polyuridylation-dependent mRNA catabolic process was marked as over-annotated. pUG tails make silencing templates, which is functional divergence from the Cid1/TUT4/7-type decay function.