Got1 (CG8430, A1ZAA5) notes

Module: dmel_aspartate_asparagine_metabolism (with Asns, Got2); also malate-aspartate shuttle partner of Mdh1.

Literature journal

• Grell 1976: two AST isozymes PMID:823072; low-activity allele PMID:823072
• Chase & Kankel 1987 (abstract only): GOT in transmitter glutamate pools PMID:3106567.
• CPTI YFP traps localisation (HDA cytosol) PMID:25294944; Got1 CPTI line also used to show expression in DN1 clock neurons and glia (PMID:32210832, not cached).
• Peroxisome is an ISM prediction from Faust 2012 PMID:22758915; Got1 C-terminus ...CENKL is not a canonical PTS1.
• UniProt lists side activities (cysteine aminotransferase, 2-aminobutanoate, cysteine sulfinate) by ARBA, from mammalian GOT1.
• Deep research: falcon timed out (see report).

Decisions

• Peroxisome ISM: UNDECIDED. Gluconeogenesis, glutamate catabolism, cysteine and aminobutanoate transaminase: KEEP_AS_NON_CORE. Rest ACCEPT.