Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
R3hdml regulates satellite cell proliferation and differentiation.
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Differentiating skeletal-muscle satellite cells secrete R3hdml.
"R3hdml protein was secreted upon satellite cell differentiation."
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R3hdml knockdown impairs myotube formation and extracellular protein rescues the defect.
"Silencing of the R3hdml gene in C2C12 cells attenuated myotube formation, and those phenotypes were rescued in the presence of R3hdml protein."
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R3hdml is required for satellite-cell proliferation, muscle development, and regeneration in mouse.
"Knockout of this gene inhibited satellite cell proliferation, skeletal muscle development, and regeneration."
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The immediate extracellular mechanism remains unresolved.
"we do not know how R3hdml affects the function of satellite cells."
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Receptor activation and extracellular-matrix/protease regulation remain alternative hypotheses.
"we speculate that it may work through the activation of certain receptors or by regulation of the ECM surrounding satellite cells via the predicted protease inhibitor functions based on R3hdml protein structure"
The CAP superfamily: cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins--roles in reproduction, cancer, and immune defense.
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CAP-family proteins are commonly secreted extracellular regulators, but family functions are diverse.
"CAP superfamily proteins are most often secreted and have an extracellular endocrine or paracrine function"
UniProt entry for human R3HDML (Q9H3Y0)
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Human R3HDML is a secreted CAP-domain precursor without an R3H domain.
"Despite its name, it does not contain a R3H domain."
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Peptidase inhibition is assigned only as a putative similarity-based function.
"FUNCTION: Putative serine protease inhibitor."
Manual literature synthesis for R3HDML