Reviewed all 28 existing rows and the core functions with the review and annotation-reviewer workflows. Preserved every machine-sourced term, evidence code, qualifier, source identifier, WITH/FROM entry and row order. No new annotations were added in this audit.
PMID:1649049 supports import-dependent precursor processing, unlike Arg7 pre-import maturation. PMID:11553611/12603335 support the kinase contribution to the NAGS complex and dispensability of the reductase for that support. The one pre-existing NEW complex annotation is preserved, not newly added. Mitochondrial DNA binding/transcription claims remain non-core on their own experimental evidence (PMID:15486299). NAD-binding inference is refined to the supported NADP specificity without asserting exclusion of every other nucleotide.
Normal publication caching completed. Normal Falcon research with Perplexity-lite fallback was attempted for this gene; authentication/quota failures prevented a generated report. Manual review used the actual cached primary sources and curated UniProt, and no provider-named research file was fabricated. Per-gene attempts and validation logs are in .cache/module-audit-logs/arginine-yeast-ARG5,6-*. Abstract-only or bibliographic-only sources are distinguished from full text in reference reviews; unavailable source details are not treated as experimental refutations.
Actions: ACCEPT 17, KEEP_AS_NON_CORE 1, MODIFY 8, NEW 1, REMOVE 1. Record sections were backfilled; focused schema/reference validation passed on the initial complete panel. Final targeted checks and HTML rendering are recorded in the audit logs.
Ontology-cache advisory: live QuickGO confirms GO:0003942 has the NADP+-specific label; the local ontology cache retains the older shorter label. The machine payload and current chemically specific label are preserved rather than rewritten to silence a stale-label warning.
Restored supported GO:0005739 mitochondrion rows to ACCEPT under the explicit root-organelle policy; existing matrix rows remain separate. Reasons distinguish organelle screens, direct targeting, publication-linked curated evidence and unavailable full text. No original annotation payload changed. Cytosol decisions use target-specific fractionation/processing evidence rather than relationship qualifiers or generic precursor transit. For Aga1, matrix inference does not imply universal post-import autoproteolysis.
The authored GO:0003942 label follows the repository ontology version; NADPH specificity remains explicit in the biological rationale. Original GOA term labels are preserved.