KLK2 notes

Deep research (falcon / perplexity-lite) failed; notes from cached publications and UniProt P20151.

• Trypsin-like, arginine-selective S1 serine protease (hK2); signal peptide 1-18, activation propeptide 19-24.
• Purified active from seminal plasma PMID:9042371.
• Activates pro-PSA, pro-hK2 and pro-uPA PMID:10209959; recombinant pro-PSA activated by hK2 PMID:9261179.
• Complexes with serpins PCI, PAI-1, ACT, PI-6 [PMID:10209959; PMID:10463585].
• Blood pressure IBA from KLK1-like clade judged over-annotation (prostate-restricted).

Localization: secreted, extracellular (seminal plasma); not cell-surface anchored.