Annotation inferences using phylogenetic trees
An ampD gene in Pseudomonas aeruginosa encodes a negative regulator of AmpC beta-lactamase expression.
Molecular mechanisms of beta-lactam resistance mediated by AmpC hyperproduction in Pseudomonas aeruginosa clinical strains.
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Some ampD mutants of clinical isolates are complemented only by ampDE, suggesting an indirect role of AmpE in resistance.
"AmpE plays an indirect role in resistance"
Regulation of enterobacterial cephalosporinase production: the role of a membrane-bound sensory transducer.
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E. coli/Enterobacter AmpE is a cytoplasmic membrane protein whose loss blocks AmpC induction; E. coli has no ampR.
"loss of AmpE results in a total block in induction, despite the presence of the activator, AmpR."
Signalling proteins in enterobacterial AmpC beta-lactamase regulation.
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AmpE is an integral membrane protein that lowers basal AmpC expression in the absence of AmpD but is not needed for induction.
"In the absence of AmpD, increasing levels of AmpE therefore decrease the basal expression of AmpC beta-lactamase in an AmpR-dependent manner."
UniProt entry G3XD69 (unreviewed)