Gene Ontology annotation through association of InterPro records with GO terms
Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
TreeGrafter-generated GO annotations
Combined Automated Annotation using Multiple IEA Methods
UniProtKB record A0A0H2MMT2 (A0A0H2MMT2_VARPD) - Phosphate regulon sensor protein PhoR from Variovorax paradoxus TBEA6
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VPARA_10420 (phoR1, A0A0H2MMT2; EC 2.7.13.3) is a 464-aa inner-membrane sensor histidine kinase (InterPro IPR014310, NCBIfam TIGR02966, PANTHER PTHR45453:SF1) containing an N-terminal transmembrane helix (residues 29-45, Pfam PF11808), a cytoplasmic PAS domain (Pfam PF00989, CDD cd00130), and a C-terminal histidine kinase domain (PROSITE PS50109, residues 216-436) with autocatalytic phosphohistidine His219.
"FT TRANSMEM 29..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 216..436
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109""
The PhoU protein from Escherichia coli interacts with PhoR, PstB, and metals to form a phosphate-signaling complex at the membrane.
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PhoR is a bifunctional histidine autokinase and phospho-PhoB phosphatase whose cytoplasmic PAS domain interacts with PhoU to sense PstSCAB transport activity.
"PhoR is the bifunctional histidine autokinase/phospho-PhoB phosphatase that donates a phosphoryl group to PhoB when environmental P i is limiting and removes the phosphoryl group from phosphorylated PhoB (PhoB∼P) when environmental P i is abundant ( 11 , 12 )."